13 Result(s)
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Article
Minsuk Kwak
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In vivo magnetogenetics for cell-type-specific targeting and modulation of brain circuits
Neuromodulation technologies are crucial for investigating neuronal connectivity and brain function. Magnetic neuromodulation offers wireless and remote deep brain stimulations that are lacking in optogenetic-...
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Author Correction: Subclonal cooperation drives metastasis by modulating local and systemic immune microenvironments
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A magnetically powered nanomachine with a DNA clutch
Machines found in nature and human-made machines share common components, such as an engine, and an output element, such as a rotor, linked by a clutch. This clutch, as seen in biological structures such as dy...
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Optimal consumption and investment with welfare constraints
This paper investigates an optimal consumption and investment problem of an economic agent who faces a welfare constraint: the agent does not accept her expected utility (continuation value) to fall below a certa...
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Human capital and portfolio choice: borrowing constraint and reversible retirement
In this paper, we investigate the impact of the option to retire and subsequently reverse that decision on an individual’s consumption and portfolio decisions. We consider two job status states: the working st...
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Open AccessMagneto-acoustic protein nanostructures for non-invasive imaging of tissue mechanics in vivo
Measuring cellular and tissue mechanics inside intact living organisms is essential for interrogating the roles of force in physiological and disease processes. Current agents for studying the mechanobiology o...
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Adherens junctions organize size-selective proteolytic hotspots critical for Notch signalling
Adherens junctions (AJs) create spatially, chemically and mechanically discrete microdomains at cellular interfaces. Here, using a mechanogenetic platform that generates artificial AJs with controlled protein ...
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Practical partial equilibrium framework for pricing of mortality-linked instruments in continuous time
This work considers a partial equilibrium approach for pricing longevity bonds in a stochastic mortality intensity setting. Thus, the pricing methodology developed in this work is based on a foundational econo...
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Open AccessA variational inequality arising from optimal surrender of variable annuity with lookback benefit
We introduce a variable annuity (VA) contract with a surrender option and lookback benefit, that is, the benefit of the VA contract is linked to the maximum process of the policyholder’s account value. In cont...
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Subclonal cooperation drives metastasis by modulating local and systemic immune microenvironments
Most human tumours are heterogeneous, composed of cellular clones with different properties present at variable frequencies. Highly heterogeneous tumours have poor clinical outcomes, yet the underlying mechani...
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Open AccessSingle-cell microRNA-mRNA co-sequencing reveals non-genetic heterogeneity and mechanisms of microRNA regulation
Measuring multiple omics profiles from the same single cell opens up the opportunity to decode molecular regulation that underlies intercellular heterogeneity in development and disease. Here, we present co-se...
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Open AccessSynergistic IL-6 and IL-8 paracrine signalling pathway infers a strategy to inhibit tumour cell migration
Following uncontrolled proliferation, a subset of primary tumour cells acquires additional traits/mutations to trigger phenotypic changes that enhance migration and are hypothesized to be the initiators of met...
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Open AccessA promising biodegradable magnesium alloy suitable for clinical vascular stent application
We report a Mg alloy Mg-2.2Nd-0.1Zn-0.4Zr (wt.%, denoted as JDBM-2) showing great potential in clinical vascular stent application by integrating the advantages of traditional medical stainless steel and polym...
