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  1. No Access

    Article

    RUNX3 enhances TRAIL-induced apoptosis by upregulating DR5 in colorectal cancer

    RUNX3 is frequently inactivated by DNA hypermethylation in numerous cancers. Here, we show that RUNX3 has an important role in modulating apoptosis in immediate response to tumor necrosis factor-related apopto...

    Bo Ram Kim, Seong Hye Park, Yoon A Jeong, Yoo ** Na, Jung Lim Kim, Min Jee Jo… in Oncogene (2019)

  2. Article

    Open Access

    Cannabidiol promotes apoptosis via regulation of XIAP/Smac in gastric cancer

    According to recent studies, Cannabidiol (CBD), one of the main components of Cannabis sativa, has anticancer effects in several cancers. However, the exact mechanism of CBD action is not currently understood. He...

    Soyeon Jeong, Min Jee Jo, Hye Kyeong Yun, Dae Yeong Kim, Bo Ram Kim… in Cell Death & Disease (2019)

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  3. No Access

    Article

    Activating CCT2 triggers Gli-1 activation during hypoxic condition in colorectal cancer

    Hypoxia, or the deficiency of oxygen, in solid tumors is majorly responsible for the progression of cancer and remains unaffected by chemotherapy, but still requires definitive definition of the hypoxia signal...

    Seong Hye Park, Soyeon Jeong, Bo Ram Kim, Yoon A Jeong, Jung Lim Kim… in Oncogene (2020)

  4. No Access

    Article

    RUNX3 suppresses metastasis and stemness by inhibiting Hedgehog signaling in colorectal cancer

    Disabled tumor suppressor genes and hyperactive oncogenes greatly contribute to cell fates during cancer development because of their genetic alterations such as somatic mutations. However, little is known abo...

    Bo Ram Kim, Yoo ** Na, Jung Lim Kim, Yoon A. Jeong… in Cell Death & Differentiation (2020)