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  1. No Access

    Article

    Population-based investigation of relative clearance of digoxin in Japanese neonates and infants by multiple-trough screen analysis

    Objective: The steady-state concentrations of digoxin at trough levels were studied to establish the role of patient characteristics in estimating doses for digoxin using routine therapeutic dru...

    Fumihiro Suematsu, Eiji Yukawa, Miho Yukawa… in European Journal of Clinical Pharmacology (2001)

  2. No Access

    Article

    Population Pharmacokinetics of Digoxin in Japanese Patients

    To clarify the observed variability of digoxin disposition by performing a population pharmacokinetic analysis in a Japanese population.

    Professor Eiji Yukawa, Fumihiro Suematu, Miho Yukawa… in Clinical Pharmacokinetics (2001)

  3. No Access

    Article

    Population Pharmacokinetics of Haloperidol Using Routine Clinical Pharmacokinetic Data in Japanese Patients

    To clarify the observed variability of haloperidol disposition in patients with psychiatric disorders.

    Eiji Yukawa, Tsuyoshi Hokazono, Miho Yukawa, Ritsuko Ichimaru… in Clinical Pharmacokinetics (2002)

  4. No Access

    Article

    Determination of Digoxin Clearance in Japanese Elderly Patients for Optimization of Drug Therapy

    Background: Optimal use of digoxin in the elderly population requires information about the drug’s pharmacokinetics and the influence of various factors on the drug’s disposition. However, becaus...

    Miho Yukawa, Dr Eiji Yukawa, Fumihiro Suematsu, Takako Takiguchi… in Drugs & Aging (2011)

  5. No Access

    Article

    Drug–tea polyphenol interaction

    Propericiazine (PCZ) is an antipsychotic agent used for the treatment and the prevention of relapse of schizophrenia. We found that when an oral solution containing PCZ was mixed with a green tea drink, the re...

    Hirohito Ikeda, Yukiko Sano… in Journal of Thermal Analysis and Calorimetry (2013)

  6. No Access

    Article

    Improving water solubility of nateglinide by complexation of β-cyclodextrin

    Inclusion complex of anionic nateglinide (NTG) with β-cyclodextrin (βCD) has been prepared to improve the water solubility of NTG. The mechanism of the complexation was elucidated using isothermal titration ca...

    Hirohito Ikeda, Yuri Fukushige… in Journal of Thermal Analysis and Calorimetry (2016)

  7. No Access

    Article

    Difference in formation mechanism of inclusion complex between configuration isomers of gallate-type catechin and β-cyclodextrin

    The formation mechanism of inclusion complex between (-)-epigallocatechin gallate (EGCg), which is the main catechin in tea leaves, or (-)-gallocatechin gallate (GCg), which is an isomer of EGCg, and β-cyclode...

    Hirohito Ikeda, Tomonori Ohata, Miho Yukawa… in Journal of Thermal Analysis and Calorimetry (2019)

  8. No Access

    Article

    Effect of solution pH on complex formation between epi-type catechin and β-cyclodextrin

    The effect of solution pH on the formation of an inclusion complex between (−)-epigallocatechin gallate (EGCg: pKa = 7.5) and β-cyclodextrin (β-CD) was investigated by isothermal titration calorimetry and 1H-NMR ...

    Tomonori Ohata, Hirohito Ikeda… in Journal of Thermal Analysis and Calorimetry (2019)

  9. No Access

    Article

    Calculation study on complex formation of catechins with β-cyclodextrin using density function theory

    The inclusion of catechins with cyclodextrin (CD) is performed for the purpose of improving the water solubility and reducing the bitterness of catechins. In this study, the effect of catechins’ conformation o...

    Hirohito Ikeda, Tomonori Ohata, Miho Yukawa… in Journal of Inclusion Phenomena and Macrocy… (2021)