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Article
Comparative benefits of social housing and buprenorphine on wheel running depressed by morphine withdrawal in rats
Social support and opioid replacement therapy are commonly used to treat opioid withdrawal.
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Article
Open AccessDepression of home cage wheel running: a reliable and clinically relevant method to assess migraine pain in rats
The development of new anti-migraine treatments is limited by the difficulty inassessing migraine pain in laboratory animals. Depression of activity is one of the few diagnostic criteria formigraine that can b...
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Article
Contribution of Adenylyl Cyclase Modulation of Pre- and Postsynaptic GABA Neurotransmission to Morphine Antinociception and Tolerance
Opioid inhibition of presynaptic GABA release in the ventrolateral periaqueductal gray (vlPAG) activates the descending antinociception pathway. Tolerance to repeated opioid administration is associated with u...
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Article
Contribution of dopamine receptors to periaqueductal gray-mediated antinociception
Morphine relieves pain, in part, by acting on neurons within the periaqueductal gray (PAG). Given that the PAG contains a subpopulation of dopamine neurons, dopamine may contribute to the antinociceptive effec...
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Article
Tolerance to Repeated Morphine Administration Is Associated with Increased Potency of Opioid Agonists
Tolerance to the pain-relieving effects of opiates limits their clinical use. Although morphine tolerance is associated with desensitization of μ-opioid receptors, the underlying cellular mechanisms are not under...
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Article
Behavioral and Electrophysiological Evidence for Opioid Tolerance in Adolescent Rats
Morphine and other opiates are successful treatments for pain, but their usefulness is limited by the development of tolerance. Given that recent studies have observed differential sensitivity to drugs of abus...
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Article
Factors That Influence Willingness to Help the Homeless
Homelessness is an ongoing challenge for many families and individuals. Many struggle to meet their basic needs for food, clothing and shelter. Unfortunately, we know very little about the people...
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Article
Different effects of chronic nicotine treatment regimens on body weight and tolerance in the rat
The effect of different chronic nicotine administration regimens on body weight and the development of tolerance was examined in female rats. Groups of animals were either treated with nicotine via a subcutane...