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    Article

    MicroRNA regulation by RNA-binding proteins and its implications for cancer

  2. Global downregulation of microRNA (miRNA) expression is an apparent feature of many tumours. Oncogenic or tumour-suppressive functions have been assigned to nu...

    3. Marieke van Kouwenhove, Martijn Kedde, Reuven Agami in Nature Reviews Cancer (2011)

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    Article

    A Pumilio-induced RNA structure switch in p27-3′ UTR controls miR-221 and miR-222 accessibility

    Quiescent cells contain high levels of both the cell cycle inhibitor p27, and the miRNAs that should negatively regulate it. In response to growth factor, the RNA-binding protein PUM1 interacts with the 3′UTR ...

    Martijn Kedde, Marieke van Kouwenhove, Wilbert Zwart… in Nature Cell Biology (2010)