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  1. Article

    Open Access

    Reversion mutations in germline BRCA1/2-mutant tumors reveal a BRCA-mediated phenotype in non-canonical histologies

    The association between loss of BRCA1/2 and a homologous recombination deficiency phenotype is lineage dependent. In BRCA-associated cancers such as breast, ovarian, pancreas and prostate, this phenotype confers ...

    Yonina R. Murciano-Goroff, Alison M. Schram, Ezra Y. Rosen… in Nature Communications (2022)

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  2. Article

    Open Access

    Ordered and deterministic cancer genome evolution after p53 loss

    Although p53 inactivation promotes genomic instability1 and presents a route to malignancy for more than half of all human cancers2,3, the patterns through which heterogenous TP53 (encoding human p53) mutant geno...

    Timour Baslan, John P. Morris IV, Zhen Zhao, Jose Reyes, Yu-Jui Ho… in Nature (2022)

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  3. Article

    Open Access

    Pilot study of bempegaldesleukin in combination with nivolumab in patients with metastatic sarcoma

    PD-1 blockade (nivolumab) efficacy remains modest for metastatic sarcoma. In this paper, we present an open-label, non-randomized, non-comparative pilot study of bempegaldesleukin, a CD122-preferential interle...

    Sandra P. D’Angelo, Allison L. Richards, Anthony P. Conley… in Nature Communications (2022)

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  4. Article

    Open Access

    AKT mutant allele-specific activation dictates pharmacologic sensitivities

    AKT- a key molecular regulator of PI-3K signaling pathway, is somatically mutated in diverse solid cancer types, and aberrant AKT activation promotes altered cancer cell growth, survival, and metabolism1–8. The m...

    Tripti Shrestha Bhattarai, Tambudzai Shamu, Alexander N. Gorelick… in Nature Communications (2022)

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  5. No Access

    Article

    Anatomic position determines oncogenic specificity in melanoma

    Oncogenic alterations to DNA are not transforming in all cellular contexts1,2. This may be due to pre-existing transcriptional programmes in the cell of origin. Here we define anatomic position as a major determi...

    Joshua M. Weiss, Miranda V. Hunter, Nelly M. Cruz, Arianna Baggiolini… in Nature (2022)

  6. Article

    Author Correction: Tumour lineage shapes BRCA-mediated phenotypes

    An Amendment to this paper has been published and can be accessed via a link at the top of the paper.

    Philip Jonsson, Chaitanya Bandlamudi, Michael L. Cheng, Preethi Srinivasan… in Nature (2020)

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  7. No Access

    Article

    Tumour lineage shapes BRCA-mediated phenotypes

    Mutations in BRCA1 and BRCA2 predispose individuals to certain cancers1–3, and disease-specific screening and preventative strategies have reduced cancer mortality in affected patients4,5. These classical tumour-...

    Philip Jonsson, Chaitanya Bandlamudi, Michael L. Cheng, Preethi Srinivasan… in Nature (2019)