Skip to main content

5 Result(s)

within Science, Humanities and Social Sciences, multidisciplinary Remove this filter Science, multidisciplinary Remove this filter Mark T. A. Donoghue Remove this filter Article Remove this filter

and
Your search also matched 2 preview-only Content is preview-only when you or your institution have not yet subscribed to it.

By making our abstracts and previews universally accessible we help you purchase only the content that is relevant to you. results, e.g.

Tumour lineage shapes BRCA-mediated phenotypes

Include preview-only content

  1. Article

    Author Correction: Tumour lineage shapes BRCA-mediated phenotypes

    An Amendment to this paper has been published and can be accessed via a link at the top of the paper.

    Philip Jonsson, Chaitanya Bandlamudi, Michael L. Cheng, Preethi Srinivasan… in Nature (2020)

    Download PDF (737 KB) View Article

  2. Article

    Open Access

    AKT mutant allele-specific activation dictates pharmacologic sensitivities

    AKT- a key molecular regulator of PI-3K signaling pathway, is somatically mutated in diverse solid cancer types, and aberrant AKT activation promotes altered cancer cell growth, survival, and metabolism1–8. The m...

    Tripti Shrestha Bhattarai, Tambudzai Shamu, Alexander N. Gorelick… in Nature Communications (2022)

    Download PDF (1770 KB) View Article

  3. Article

    Open Access

    Pilot study of bempegaldesleukin in combination with nivolumab in patients with metastatic sarcoma

    PD-1 blockade (nivolumab) efficacy remains modest for metastatic sarcoma. In this paper, we present an open-label, non-randomized, non-comparative pilot study of bempegaldesleukin, a CD122-preferential interle...

    Sandra P. D’Angelo, Allison L. Richards, Anthony P. Conley… in Nature Communications (2022)

    Download PDF (979 KB) View Article

  4. Article

    Open Access

    Ordered and deterministic cancer genome evolution after p53 loss

    Although p53 inactivation promotes genomic instability1 and presents a route to malignancy for more than half of all human cancers2,3, the patterns through which heterogenous TP53 (encoding human p53) mutant geno...

    Timour Baslan, John P. Morris IV, Zhen Zhao, Jose Reyes, Yu-Jui Ho… in Nature (2022)

    Download PDF (47107 KB) View Article

  5. Article

    Open Access

    Reversion mutations in germline BRCA1/2-mutant tumors reveal a BRCA-mediated phenotype in non-canonical histologies

    The association between loss of BRCA1/2 and a homologous recombination deficiency phenotype is lineage dependent. In BRCA-associated cancers such as breast, ovarian, pancreas and prostate, this phenotype confers ...

    Yonina R. Murciano-Goroff, Alison M. Schram, Ezra Y. Rosen… in Nature Communications (2022)

    Download PDF (3374 KB) View Article