13 Result(s)
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Article
Mark Novotny
English
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Article
SARS-CoV-2 infection of the oral cavity and saliva
Despite signs of infection—including taste loss, dry mouth and mucosal lesions such as ulcerations, enanthema and macules—the involvement of the oral cavity in coronavirus disease 2019 (COVID-19) is poorly und...
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Open AccessTranscriptomic evidence that von Economo neurons are regionally specialized extratelencephalic-projecting excitatory neurons
von Economo neurons (VENs) are bipolar, spindle-shaped neurons restricted to layer 5 of human frontoinsula and anterior cingulate cortex that appear to be selectively vulnerable to neuropsychiatric and neurode...
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Transcriptomic and morphophysiological evidence for a specialized human cortical GABAergic cell type
We describe convergent evidence from transcriptomics, morphology, and physiology for a specialized GABAergic neuron subtype in human cortex. Using unbiased single-nucleus RNA sequencing, we identify ten GABAer...
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Author Correction: L1-associated genomic regions are deleted in somatic cells of the healthy human brain
In the version of this article initially published, NIH grant U01 MH106882 to F.H.G. was missing from the Acknowledgments. The error has been corrected in the HTML and PDF versions of the article.
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Open AccessCell type discovery and representation in the era of high-content single cell phenoty**
A fundamental characteristic of multicellular organisms is the specialization of functional cell types through the process of differentiation. These specialized cell types not only characterize the normal func...
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Correction: Corrigendum: L1-associated genomic regions are deleted in somatic cells of the healthy human brain
Nat. Neurosci. 19, 1583–1591 (2016); published online 12 September 2016; corrected after print 13 July 2017 In the version of this article initially published, NIH grant T32 CA009370 to F.H.G. was missing from...
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Open AccessCorrection: Corrigendum: Nuclear RNA-seq of single neurons reveals molecular signatures of activation
Nature Communications 7: Article number: 11022 (2016); Published 19 April 2016; Updated 17 March 2017 An incorrect version of Supplementary Data 1, in which normalized counts were analysed instead of raw count...
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L1-associated genomic regions are deleted in somatic cells of the healthy human brain
The healthy human brain is a mosaic of varied genomes. Using a single cell sequencing approach targeting L1 elements, the authors show that the contribution of L1 to somatic mosaicism goes beyond retrotranspos...
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Open AccessCorrection: Corrigendum: Nuclear RNA-seq of single neurons reveals molecular signatures of activation
Nature Communications 7: Article number:11022 (2016); Published 19 April 2016; Updated 14 June 2016 In the original version of this Article, the middle names or initials of the authors Suguna Rani Krishnaswami...
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Open AccessNuclear RNA-seq of single neurons reveals molecular signatures of activation
Single-cell sequencing methods have emerged as powerful tools for identification of heterogeneous cell types within defined brain regions. Application of single-cell techniques to study the transcriptome of ac...
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Using single nuclei for RNA-seq to capture the transcriptome of postmortem neurons
This protocol describes how to sequence the transcriptome from a single nucleus. It is particularly suited to cell types that are difficult to isolate as intact whole cells, such as neurons.
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Efficient de novo assembly of single-cell bacterial genomes from short-read data sets
DNA can be amplified and sequenced from a single cell, but unevenness of the sequence coverage complicates efforts to assemble a high-quality genome. Chitsaz et al. devise an algorithm to address this problem and...
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A modified walking rhythm employed during righting behavior in the cockroachGromphadorhina portentosa
Electromyograms were recorded from leg muscles of the cockroachGromphadorhina during walking and righting under free-ranging and tethered conditions. Two muscles which are essentially synergistic during walking b...
