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Article
Heme catabolism by tumor-associated macrophages controls metastasis formation
Although the pathological significance of tumor-associated macrophage (TAM) heterogeneity is still poorly understood, TAM reprogramming is viewed as a promising anticancer therapy. Here we show that a distinct...
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Article
Macrophage polarization in pathology
Macrophages are cells of the innate immunity constituting the mononuclear phagocyte system and endowed with remarkable different roles essential for defense mechanisms, development of tissues, and homeostasis....
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Article
Tumor-associated Macrophages (TAM) and Inflammation in Colorectal Cancer
Experimental and epidemiological studies indicate a strong link between chronic inflammation and tumor progression. Human colorectal cancer (CRC), a major cause of cancer-related death in Western countries, re...