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  1. No Access

    Article

    Heme catabolism by tumor-associated macrophages controls metastasis formation

    Although the pathological significance of tumor-associated macrophage (TAM) heterogeneity is still poorly understood, TAM reprogramming is viewed as a promising anticancer therapy. Here we show that a distinct...

    Francesca Maria Consonni, Augusto Bleve, Maria Grazia Totaro… in Nature Immunology (2021)

  2. Article

    Open Access

    Senescent thyrocytes and thyroid tumor cells induce M2-like macrophage polarization of human monocytes via a PGE2-dependent mechanism

    Thyroid carcinoma includes several variants characterized by different biological and clinical features: from indolent microcarcinoma to undifferentiated and aggressive anaplastic carcinoma. Inflammation plays...

    Mara Mazzoni, Giuseppe Mauro, Marco Erreni… in Journal of Experimental & Clinical Cancer … (2019)

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    Article

    Tumor-associated Macrophages (TAM) and Inflammation in Colorectal Cancer

    Experimental and epidemiological studies indicate a strong link between chronic inflammation and tumor progression. Human colorectal cancer (CRC), a major cause of cancer-related death in Western countries, re...

    Marco Erreni, Alberto Mantovani, Paola Allavena in Cancer Microenvironment (2011)