26 Result(s)

Article

Postnatal serum IGF-1 levels associate with brain volumes at term in extremely preterm infants

Growth factors important for normal brain development are low in preterm infants. This study investigated the link between growth factors and preterm brain volumes at term.

William Hellström, Lisa M. Hortensius, Chatarina Löfqvist… in Pediatric Research (2023)

Article

Mammillary body injury in neonatal encephalopathy: a multicentre, retrospective study

The mammillary bodies (MBs) have repeatedly been shown to be critical for memory, yet little is known about their involvement in numerous neurological conditions linked to memory impairments, including neonata...

Maarten. H. Lequin, Sylke. J. Steggerda, Mariasavina Severino… in Pediatric Research (2022)

Article

NutriBrain: protocol for a randomised, double-blind, controlled trial to evaluate the effects of a nutritional product on brain integrity in preterm infants

The gut microbiota and the brain are connected through different mechanisms. Bacterial colonisation of the gut plays a substantial role in normal brain development, providing opportunities for nutritional neur...

Lisa M. Hortensius, Edith H. van den Hooven, Jeroen Dudink… in BMC Pediatrics (2021)

Article

The development and validation of a cerebral ultrasound scoring system for infants with hypoxic-ischaemic encephalopathy

Hypoxic-ischaemic encephalopathy (HIE) is an important cause of morbidity and mortality in neonates. When the gold standard MRI is not feasible, cerebral ultrasound (CUS) might offer an alternative. In this st...

Kim V. Annink, Linda S. de Vries, Floris Groenendaal… in Pediatric Research (2020)

Article

Effect of allopurinol in addition to hypothermia treatment in neonates for hypoxic-ischemic brain injury on neurocognitive outcome (ALBINO): study protocol of a blinded randomized placebo-controlled parallel group multicenter trial for superiority (phase III)

Perinatal asphyxia and resulting hypoxic-ischemic encephalopathy is a major cause of death and long-term disability in term born neonates. Up to 20,000 infants each year are affected by HIE in Europe and even ...

Christian A. Maiwald, Kim V. Annink, Mario Rüdiger… in BMC Pediatrics (2019)

Article

Mild cerebellar injury does not significantly affect cerebral white matter microstructural organization and neurodevelopmental outcome in a contemporary cohort of preterm infants

Preterm birth is associated with an increased risk of cerebellar injury. The aim of this study was to assess the impact of cerebellar hemorrhages (CBH) on cerebral white matter microstructural tissue organizat...

Richelle E M Senden, Kristin Keunen, Niek E van der Aa… in Pediatric Research (2018)

Article

Severe retinopathy of prematurity is associated with reduced cerebellar and brainstem volumes at term and neurodevelopmental deficits at 2 years

To evaluate the association between severe retinopathy of prematurity (ROP), measures of brain morphology at term-equivalent age (TEA), and neurodevelopmental outcome.

Femke J Drost, Kristin Keunen, Pim Moeskops, Nathalie H P Claessens… in Pediatric Research (2018)

Article

Changes in brain morphology and microstructure in relation to early brain activity in extremely preterm infants

To investigate the relation of early brain activity with structural (growth of the cortex and cerebellum) and white matter microstructural brain development.

Maria Luisa Tataranno, Nathalie H P Claessens, Pim Moeskops… in Pediatric Research (2018)

Article

Effects of early nutrition and growth on brain volumes, white matter microstructure, and neurodevelopmental outcome in preterm newborns

This study aimed to investigate the effect of nutrition and growth during the first 4 weeks after birth on cerebral volumes and white matter maturation at term equivalent age (TEA) and on neurodevelopmental ou...

Caterina Coviello, Kristin Keunen, Karina J Kersbergen… in Pediatric Research (2018)

Article

Promoting neuroregeneration after perinatal arterial ischemic stroke: neurotrophic factors and mesenchymal stem cells

Newborns suffering from perinatal arterial ischemic stroke (PAIS) are at risk of neurodevelopmental problems. Current treatment options for PAIS are limited and mainly focus on supportive care, as presentation...

Nienke Wagenaar, Caroline G M de Theije, Linda S de Vries… in Pediatric Research (2018)

Article

Delayed cortical gray matter development in neonates with severe congenital heart disease

This study aimed to assess cortical gray matter growth and maturation in neonates with congenital heart disease (CHD).

Nathalie H.P. Claessens, Pim Moeskops, Andreas Buchmann… in Pediatric Research (2016)

Article

Editor’s Focus

Nathalie H.P. Claessens, Pim Moeskops, Andreas Buchmann… in Pediatric Research (2016)

Article

Magnetic resonance imaging based noninvasive measurements of brain hemodynamics in neonates: a review

Perinatal disturbances of brain hemodynamics can have a detrimental effect on the brain’s parenchyma with consequently adverse neurodevelopmental outcome. Noninvasive, reliable tools to evaluate the neonate’s ...

Jill B. De Vis, Thomas Alderliesten, Jeroen Hendrikse… in Pediatric Research (2016)

Article

Impact of nutrition on brain development and its neuroprotective implications following preterm birth

The impact of nutrition on brain development in preterm infants has been increasingly appreciated. Early postnatal growth and nutrient intake have been demonstrated to influence brain growth and maturation wit...

Kristin Keunen, Ruurd M. van Elburg, Frank van Bel… in Pediatric Research (2015)

Article

Evaluation of perinatal arterial ischemic stroke using noninvasive arterial spin labeling perfusion MRI

Arterial spin labeling (ASL) magnetic resonance imaging (MRI) can evaluate brain perfusion in neonates noninvasively. The aim of this study was to investigate whether ASL MRI can demonstrate perfusion abnormal...

Jill B. De Vis, Esben T. Petersen, Karina J. Kersbergen… in Pediatric Research (2013)

Article

Cerebral oxygenation and brain activity after perinatal asphyxia: does hypothermia change their prognostic value?

Hypothermia is an established therapy in term neonates to reduce death and disability after perinatal asphyxia. Near-infrared spectroscopy-monitored regional cerebral oxygen saturation (rScO₂) and amplitude-integ...

Petra M.A. Lemmers, Renee J. Zwanenburg, Manon J.N.L. Benders… in Pediatric Research (2013)

Article

Quantification of white matter injury following neonatal stroke with serial DTI

Diffusion tensor imaging (DTI) can be used to predict outcome following perinatal arterial ischemic stroke (PAIS), although little is known about white matter changes over time.

Niek E. van der Aa, Frances J. Northington, Brian S. Stone… in Pediatric Research (2013)

Article

Use of cardiac biomarkers in neonatology

Cardiac biomarkers are used to identify cardiac disease in term and preterm infants. This review discusses the roles of natriuretic peptides and cardiac troponins. Natriuretic peptide levels are elevated durin...

Daniel C. Vijlbrief, Manon J.N.L. Benders, Hans Kemperman… in Pediatric Research (2012)

Article

Changes in carotid blood flow after unilateral perinatal arterial ischemic stroke

Little is known about changes in carotid blood flow after perinatal arterial ischemic stroke (PAIS). The aim of this study was to assess the blood flow in the internal carotid arteries (ICAs) after unilateral ...

Niek E. van der Aa, Eva D. Porsius, Jeroen Hendrikse… in Pediatric Research (2012)

Article

Hydrocortisone vs. dexamethasone treatment for bronchopulmonary dysplasia and their effects on general movements in preterm infants

Hydrocortisone (HC) and dexamethasone (DXM) are used to treat preterm infants at risk for bronchopulmonary dysplasia (BPD). This may, however, affect their long-term neurological development. We aimed to deter...

Marrit M. Hitzert, Manon J.N.L. Benders, Annemiek M. Roescher… in Pediatric Research (2012)