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Article
Open AccessSystems approaches identify the consequences of monosomy in somatic human cells
Chromosome loss that results in monosomy is detrimental to viability, yet it is frequently observed in cancers. How cancers survive with monosomy is unknown. Using p53-deficient monosomic cell lines, we find t...
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Article
Open AccessLearning (from) the errors of a systems biology model
Mathematical modelling is a labour intensive process involving several iterations of testing on real data and manual model modifications. In biology, the domain knowledge guiding model development is in many c...
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Article
Correction: Corrigendum: Replication stress links structural and numerical cancer chromosomal instability
Nature 494, 492–496 (2013); doi:10.1038/nature11935 In this Letter we inadvertently omitted full details of The Cancer Genome Atlas data sets. The Acknowledgements should have included these sentences: “The re...
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Article
Replication stress links structural and numerical cancer chromosomal instability
A mechanism to explain chromosomal instability (CIN) in colorectal cancer is demonstrated; three new CIN-suppressor genes (PIGN, MEX3C and ZNF516) encoded on chromosome 18q are identified, the loss of which leads...