30 Result(s)

Article

The contribution of genetics and epigenetics to MAFLD susceptibility

Metabolic dysfunction-associated fatty liver disease (MAFLD) is the most common liver disease worldwide. The risk of develo** MAFLD varies among individuals, due to a combination of environmental inherited a...

Vittoria Moretti, Stefano Romeo, Luca Valenti in Hepatology International (2024)

Article

Author Correction: Interaction between estrogen receptor-α and PNPLA3 p.I148M variant drives fatty liver disease susceptibility in women

Alessandro Cherubini, Mahnoosh Ostadreza, Oveis Jamialahmadi… in Nature Medicine (2024)

Article

Author Correction: Consensus Statement on the definition and classification of metabolic hyperferritinaemia

Luca Valenti, Elena Corradini, Leon A. Adams, Elmar Aigner… in Nature Reviews Endocrinology (2024)

Article

Population-based prevalence and mutational landscape of von Willebrand disease using large-scale genetic databases

Von Willebrand disease (VWD) is a common bleeding disorder caused by mutations in the von Willebrand factor gene (VWF). The true global prevalence of VWD has not been accurately established. We estimated the worl...

Omid Seidizadeh, Andrea Cairo, Luciano Baronciani, Luca Valenti… in npj Genomic Medicine (2023)

Article

Interaction between estrogen receptor-α and PNPLA3 p.I148M variant drives fatty liver disease susceptibility in women

Fatty liver disease (FLD) caused by metabolic dysfunction is the leading cause of liver disease and the prevalence is rising, especially in women. Although during reproductive age women are protected against F...

Alessandro Cherubini, Mahnoosh Ostadreza, Oveis Jamialahmadi… in Nature Medicine (2023)

Article

Incidence, microbiological and immunological characteristics of ventilator-associated pneumonia assessed by bronchoalveolar lavage and endotracheal aspirate in a prospective cohort of COVID-19 patients: CoV-AP study

No univocal recommendation exists for microbiological diagnosis of ventilator-associated pneumonia (VAP). Sampling of either proximal or distal respiratory tract likely impacts on the broad range of VAP incide...

Davide Mangioni, Mauro Panigada, Emanuele Palomba, Chiara Bobbio… in Critical Care (2023)

Article

Consensus Statement on the definition and classification of metabolic hyperferritinaemia

Hyperferritinaemia is a common laboratory finding that is often associated with metabolic dysfunction and fatty liver. Metabolic hyperferritinaemia reflects alterations in iron metabolism that facilitate iron ...

Luca Valenti, Elena Corradini, Leon A. Adams, Elmar Aigner… in Nature Reviews Endocrinology (2023)

Article

Correction to: Usefulness of Fibrosis-4 (FIB-4) score and metabolic alterations in the prediction of SARS-CoV-2 severity

Rosa Lombardi, Vincenzo La Mura, Annalisa Cespiati… in Internal and Emergency Medicine (2022)

Article

Usefulness of fibrosis-4 (FIB-4) score and metabolic alterations in the prediction of SARS-CoV-2 severity

Despite vaccination programs, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remains a public health problem. Identifying key prognostic determinants of severity of the disease may help...

Rosa Lombardi, Vincenzo La Mura, Annalisa Cespiati… in Internal and Emergency Medicine (2022)

Article

Metabolic and genetic determinants for progression to severe liver disease in subjects with obesity from the UK Biobank

Obesity is among the main determinants of nonalcoholic fatty liver disease progression towards severe liver disease (SLD). However, risk factors for SLD in individuals with obesity have not been examined.

Antonio De Vincentis, Federica Tavaglione… in International Journal of Obesity (2022)

Article

PSD3 downregulation confers protection against fatty liver disease

Fatty liver disease (FLD) is a growing health issue with burdening unmet clinical needs. FLD has a genetic component but, despite the common variants already identified, there is still a missing heritability c...

Rosellina M. Mancina, Kavitha Sasidharan, Anna Lindblom, Ying Wei… in Nature Metabolism (2022)

Article

Advancing the global public health agenda for NAFLD: a consensus statement

Non-alcoholic fatty liver disease (NAFLD) is a potentially serious liver disease that affects approximately one-quarter of the global adult population, causing a substantial burden of ill health with wide-rang...

Jeffrey V. Lazarus, Henry E. Mark… in Nature Reviews Gastroenterology & Hepatolo… (2022)

Article

Targeting of eIF6-driven translation induces a metabolic rewiring that reduces NAFLD and the consequent evolution to hepatocellular carcinoma

A postprandial increase of translation mediated by eukaryotic Initiation Factor 6 (eIF6) occurs in the liver. Its contribution to steatosis and disease is unknown. In this study we address whether eIF6-driven ...

Alessandra Scagliola, Annarita Miluzio, Gabriele Ventura… in Nature Communications (2021)

Article

Adipocyte PHLPP2 inhibition prevents obesity-induced fatty liver

Increased adiposity confers risk for systemic insulin resistance and type 2 diabetes (T2D), but mechanisms underlying this pathogenic inter-organ crosstalk are incompletely understood. We find PHLPP2 (PH domai...

Kyeong** Kim, ** Ku Kang, Young Hoon Jung, Sang Bae Lee… in Nature Communications (2021)

Article

The TM6SF2 E167K genetic variant induces lipid biosynthesis and reduces apolipoprotein B secretion in human hepatic 3D spheroids

There is a high unmet need for develo** treatments for nonalcoholic fatty liver disease (NAFLD), for which there are no approved drugs today. Here, we used a human in vitro disease model to understand mechanism...

Sebastian Prill, Andrea Caddeo, Guido Baselli, Oveis Jamialahmadi… in Scientific Reports (2019)

Article

The effect of the TM6SF2 E167K variant on liver steatosis and fibrosis in patients with chronic hepatitis C: a meta-analysis

The impact of Transmembrane 6 superfamily member 2 (TM6SF2) E167K variant, which causes hepatocellular fat retention by altering lipoprotein secretion, on liver damage and metabolic traits in chronic hepatitis C ...

Zhengtao Liu, Shu** Que, Lin Zhou, Shusen Zheng, Stefano Romeo… in Scientific Reports (2017)

Article

MBOAT7 rs641738 variant and hepatocellular carcinoma in non-cirrhotic individuals

Nonalcoholic fatty liver disease (NAFLD) represents an emerging cause of hepatocellular carcinoma (HCC), especially in non-cirrhotic individuals. The rs641738 C > T MBOAT7/TMC4 variant predisposes to progressive ...

Benedetta Donati, Paola Dongiovanni, Stefano Romeo, Marica Meroni… in Scientific Reports (2017)