18 Result(s)
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Article
LiangKai Chen
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Open AccessLife’s essential 8, genetic susceptibility, and risk of inflammatory bowel diseases: a population-based cohort study
Evidence has shown that the individual metrics in Life’s Essential 8 (LE8), an updated cardiovascular health (CVH) concept proposed by the American Heart Association, play a role in the development of inflamma...
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Association of the serum levels of saturated fatty acids and mild cognitive impairment: a cross-sectional study
To investigate the association of serum saturated fatty acids (SFAs) and prevalent mild cognitive impairment (MCI) among middle-aged and elderly Chinese.
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Open AccessSerum urate levels and neurodegenerative outcomes: a prospective cohort study and mendelian randomization analysis of the UK Biobank
Previous studies on the associations between serum urate levels and neurodegenerative outcomes have yielded inconclusive results, and the causality remains unclear. This study aimed to investigate whether urat...
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Open AccessGlobal epidemiology of type 2 diabetes in patients with NAFLD or MAFLD: a systematic review and meta-analysis
Non-alcoholic fatty liver disease (NAFLD) and metabolic-associated fatty liver disease (MAFLD) shares common pathophysiological mechanisms with type 2 diabetes, making them significant risk factors for type 2 ...
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Open AccessGenome-wide association analysis of left ventricular imaging-derived phenotypes identifies 72 risk loci and yields genetic insights into hypertrophic cardiomyopathy
Left ventricular regional wall thickness (LVRWT) is an independent predictor of morbidity and mortality in cardiovascular diseases (CVDs). To identify specific genetic influences on individual LVRWT, we establ...
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Open AccessPlant-based dietary patterns, genetic predisposition and risk of colorectal cancer: a prospective study from the UK Biobank
Plant-based dietary patterns may affect colorectal cancer (CRC) related outcomes, while risks differ in the quality of plant foods. We aimed to examine the association of plant-based diet quality with risks of...
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Open AccessPlant-based diets, genetic predisposition and risk of non-alcoholic fatty liver disease
Diets rich in plant-based foods are associated with lower risks of non-alcoholic fatty liver disease (NAFLD), while the prospective evidence is limited. We aimed to examine longitudinal associations of plant-b...
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Open AccessEating habit of adding salt to foods and incident sleep apnea: a prospective cohort study
Previous studies have revealed that sodium-restricted diet intervention significantly decreased apnea frequency among patients with sleep apnea. However, the longitudinal association between the habit of addin...
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Open AccessFrequency of adding salt at the table and risk of incident cardiovascular disease and all-cause mortality: a prospective cohort study
Adding salt at the table is a prevalent eating habit, but its long-term relationship with cardiovascular disease (CVD) and all-cause mortality remains unclear. We evaluated the associations of adding salt at t...
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Open AccessAssociations of physical activity intensity with incident cardiovascular diseases and mortality among 366,566 UK adults
The associations of the proportion of vigorous physical activity (VPA) to moderate to vigorous physical activity (MVPA) with incident cardiovascular disease (CVD) and all-cause mortality are unclear.
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Open AccessFrailty and risk of microvascular complications in patients with type 2 diabetes: a population-based cohort study
Cross-sectional studies found that frailty was associated with prevalent diabetic microvascular complications (DMC). Longitudinal evidence in this regard is inconclusive and insufficient. We aimed to prospecti...
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DHPPA, a major plasma alkylresorcinol metabolite reflecting whole-grain wheat and rye intake, and risk of metabolic syndrome: a case–control study
Whole-grain intake assessed through self-reported methods has been suggested to be inversely associated with the metabolic syndrome (MetS) risk in epidemiological studies. However, few studies have evaluated t...
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Open AccessMendelian randomization analysis of 37 clinical factors and coronary artery disease in East Asian and European populations
Coronary artery disease (CAD) remains the leading cause of mortality worldwide despite enormous efforts devoted to its prevention and treatment. While many genetic loci have been identified to associate with C...
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Open AccessSARS-CoV-2 infection induces sustained humoral immune responses in convalescent patients following symptomatic COVID-19
Long-term antibody responses and neutralizing activities in response to SARS-CoV-2 infection are not yet clear. Here we quantify immunoglobulin M (IgM) and G (IgG) antibodies recognizing the SARS-CoV-2 recepto...
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Open AccessClinical characteristics of “re-positive” discharged COVID-19 pneumonia patients in Wuhan, China
To analyze the clinical characteristics of re-positive discharged COVID-19 patients and find distinguishing markers. The demographic features, clinical symptoms, laboratory results, comorbidities, co-infection...
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Multi-residue determination of 325 pesticides in chicken eggs with EMR-Lipid clean-up by UHPLC–MS/MS and GC–MS/MS
Eggs are one of the most common foods in the world, and their safety is a major concern for the public. We aimed to develop a novel clean-up approach named Bond Elut Enhanced Matrix Removal-Lipid (EMR-Lipid) f...
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Heme oxygenase-1 regulates autophagy through carbon–oxygen to alleviate deoxynivalenol-induced hepatic damage
Deoxynivalenol (DON) cannot be totally removed due to its stable chemical characteristics and chronic exposure to low doses of DON causes significant toxic effects in humans and animals. However, the potential...
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Open AccessEffectiveness evaluation of quota payment for specific diseases under global budget: a typical provider payment system reform in rural China
Quota payment for specific diseases under global budget is one of the most typical modes of provider payment system reform in rural China. This study aimed to assess this reform mode from aspects of the total ...
