716 Result(s)

Article

Inhibition of PKC-δ retards kidney fibrosis via inhibiting cGAS-STING signaling pathway in mice

Kidney fibrosis is considered to be the ultimate aggregation pathway of chronic kidney disease (CKD), but its underlying mechanism remains elusive. Protein kinase C-delta (PKC-δ) plays critical roles in the co...

Dongyun Wang, Yue Li, Guiying Li, Mengyu Liu, Zihui Zhou, Ming Wu… in Cell Death Discovery (2024)

Article

Localized, highly efficient secretion of signaling proteins by migrasomes

Migrasomes, enriched with signaling molecules such as chemokines, cytokines and angiogenic factors, play a pivotal role in the spatially defined delivery of these molecules, influencing critical physiological ...

Haifeng Jiao, **aopeng Li, Ying Li, Yuting Guo, **aoyu Hu, Takami Sho… in Cell Research (2024)

Article

ALKBH4 impedes 5-FU Sensitivity through suppressing GSDME induced pyroptosis in gastric cancer

5-Fluorouracil (5-FU) is the primary treatment option for advanced gastric cancer. However, the current challenge lies in the absence of validated biomarkers to accurately predict the efficacy and sensitivity ...

**n Jiang, Zhiman Zhu, Lina Ding, Wenqi Du, Dongsheng Pei in Cell Death & Disease (2024)

Article

TMC6 functions as a GPCR-like receptor to sense noxious heat via Gαq signaling

Thermosensation is vital for the survival, propagation, and adaption of all organisms, but its mechanism is not fully understood yet. Here, we find that TMC6, a membrane protein of unknown function, is highly ...

Chen Zhang, Fang Tong, Bin Zhou, Mingdong He, Shuai Liu, **aomeng Zhou… in Cell Discovery (2024)

Article

Nicotine-induced activation of cholinergic receptor nicotinic alpha 5 subunit mediates the malignant behaviours of laryngeal squamous epithelial cells by interacting with RABL6

Nicotine, a crucial constituent of tobacco smoke, can bind to and activate nicotinic acetylcholine receptors (nAChRs), thereby regulating various biological functions. However, the specific mechanisms through ...

Yujie Shen, Qiang Huang, **aohui Yuan, Hongli Gong, Chengzhi Xu… in Cell Death Discovery (2024)

Article

Glucose deprivation triggers DCAF1-mediated inactivation of Rheb-mTORC1 and promotes cancer cell survival

Low glucose is a common microenvironment for rapidly growing solid tumors, which has developed multiple approaches to survive under glucose deprivation. However, the specific regulatory mechanism remains large...

Miaomiao Li, Wen**g Huang, Yuan Zhang, Yue Du, Shan Zhao… in Cell Death & Disease (2024)

Article

Author Correction: A genetically encoded ratiometric indicator for tryptophan

Rongkun Tao, Kui Wang, Tian-lun Chen, **n-xin Zhang, Jian-bin Cao… in Cell Discovery (2024)

Article

Pyruvate kinase M2 sustains cardiac mitochondrial quality surveillance in septic cardiomyopathy by regulating prohibitin 2 abundance via S91 phosphorylation

The endogenous mitochondrial quality control (MQC) system serves to protect mitochondria against cellular stressors. Although mitochondrial dysfunction contributes to cardiac damage during many pathological co...

Yingzhen Du, Jialei Li, Zhe Dai, Yuxin Chen… in Cellular and Molecular Life Sciences (2024)

Article

Three-dimensional chromatin reorganization regulates B cell development during ageing

The contribution of three-dimensional genome organization to physiological ageing is not well known. Here we show that large-scale chromatin reorganization distinguishes young and old bone marrow progenitor (p...

Fei Ma, Yaqiang Cao, Hansen Du, Fatima Zohra Braikia, Le Zong… in Nature Cell Biology (2024)

Article

Targeting ARNT attenuates chemoresistance through destabilizing p38α-MAPK signaling in glioblastoma

Glioblastoma (GBM) is the most aggressive and lethal brain tumor in adults. This study aimed to investigate the functional significance of aryl hydrocarbon receptor nuclear translocator (ARNT) in the pathogene...

Wahafu Alafate, Gen Lv, Jiantao Zheng, Hai** Cai, Wei Wu… in Cell Death & Disease (2024)

Article

Inhibition of lysosomal TRPML1 channel eliminates breast cancer stem cells by triggering ferroptosis

Cancer stem cells (CSCs) are a sub-population of cells possessing high tumorigenic potential, which contribute to therapeutic resistance, metastasis and recurrence. Eradication of CSCs is widely recognized as ...

Chunhong Fan, Haotian Wu, **n Du, Canjun Li, Wen** Zeng, Lili Qu… in Cell Death Discovery (2024)

Article

Transcriptomic profiling and regulatory pathways of cardiac resident macrophages in aging

Cardiovascular diseases are an array of age-related disorders, and accumulating evidence suggests a link between cardiac resident macrophages (CRMs) and the age-related disorders. However, how does CRMs alter ...

Guofang **a, Simeng Zhu, Yujia Liu, **gwei Pan… in Cellular and Molecular Life Sciences (2024)

Article

IDH1 mutation produces R-2-hydroxyglutarate (R-2HG) and induces mir-182-5p expression to regulate cell cycle and tumor formation in glioma

Mutations in isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2), are present in most gliomas. IDH1 mutation is an important prognostic marker in glioma. However, its regulatory mechanism in glioma remains incomplet...

Haiting Zhao, Li Meng, Peng Du, **nbin Liao, **n Mo, Mengqi Gong… in Biological Research (2024)

Article

U3 snoRNA inter-regulates with DDX21 in the perichromosomal region to control mitosis

U3 snoRNA is essential for ribosome biogenesis during interphase. Upon mitotic onset, the nucleolus disassembles and U3 snoRNA relocates to the perichromosomal region (PR) to be considered as a chromosome pass...

Yang Jiang, Shiqi Sun, **aofeng Liu, Kunqi Su, Chunfeng Zhang… in Cell Death & Disease (2024)

Article

E3 ubiquitin ligase UBR5 promotes gemcitabine resistance in pancreatic cancer by inducing O-GlcNAcylation-mediated EMT via destabilization of OGA

Pancreatic cancer (PC) is among the deadliest malignancies, with an extremely poor diagnosis and prognosis. Gemcitabine (GEM) remains the first-line drug for treating PC; however, only a small percentage of pa...

Yunyan Du, Zhangjian Yang, Hao Shi, Zhihan Chen, Rong Chen… in Cell Death & Disease (2024)