245 Result(s)

Article

Correction: MELK is an oncogenic kinase essential for metastasis, mitotic progression, and programmed death in lung carcinoma

Qin Tang, Wan Li, **ang** Zheng, Liwen Ren… in Signal Transduction and Targeted Therapy (2024)

Article

A Cullin 5-based complex serves as an essential modulator of ORF9b stability in SARS-CoV-2 replication

The ORF9b protein, derived from the nucleocapsid’s open-reading frame in both SARS-CoV and SARS-CoV-2, serves as an accessory protein crucial for viral immune evasion by inhibiting the innate immune response. ...

Yuzheng Zhou, Zongpeng Chen, Sijie Liu… in Signal Transduction and Targeted Therapy (2024)

Article

Engineered extracellular vesicles for targeted reprogramming of cancer-associated fibroblasts to potentiate therapy of pancreatic cancer

Pancreatic cancer is one of the deadly malignancies with a significant mortality rate and there are currently few therapeutic options for it. The tumor microenvironment (TME) in pancreatic cancer, distinguishe...

Pengcheng Zhou, Xuanlong Du, Weilu Jia… in Signal Transduction and Targeted Therapy (2024)

Article

First-line penpulimab (an anti-PD1 antibody) and anlotinib (an angiogenesis inhibitor) with nab-paclitaxel/gemcitabine (PAAG) in metastatic pancreatic cancer: a prospective, multicentre, biomolecular exploratory, phase II trial

Metastatic pancreatic cancer (mPC) has a dismal prognosis. Herein, we conducted a prospective, multicentre, single-arm, phase II trial evaluating the efficacy and safety of penpulimab and anlotinib in combinat...

Huizi Sha, Fan Tong, Jiayao Ni, Yi Sun… in Signal Transduction and Targeted Therapy (2024)

Article

An E3 ligase TRIM1 promotes colorectal cancer progression via K63-linked ubiquitination and activation of HIF1α

Accumulating studies have shown that E3 ligases play crucial roles in regulating cellular biological processes and signaling pathways during carcinogenesis via ubiquitination. Tripartite-motif (TRIM) ubiquitin...

Liuliu Shi, **anglan Fang, Lijie Du, ** Yang, Juan Xue, **aokai Yue… in Oncogenesis (2024)

Article

LncRNA MIR31HG fosters stemness malignant features of non-small cell lung cancer via H3K4me1- and H3K27Ace-mediated GLI2 expression

Non-coding RNAs are responsible for oncogenesis and the development of stemness features, including multidrug resistance and metastasis, in various cancers. Expression of lncRNA MIR31HG in lung cancer tissues ...

Weiwei Chen, Fei Wang, **nyuan Yu, **g**g Qi, Hongliang Dong, Bingjie Cui… in Oncogene (2024)

Article

XELOX (capecitabine plus oxaliplatin) plus bevacizumab (anti-VEGF-A antibody) with or without adoptive cell immunotherapy in the treatment of patients with previously untreated metastatic colorectal cancer: a multicenter, open-label, randomized, controlled, phase 3 trial

Fluoropyrimidine-based combination chemotherapy plus targeted therapy is the standard initial treatment for unresectable metastatic colorectal cancer (mCRC), but the prognosis remains poor. This phase 3 trial ...

Qiu-Zhong Pan, **g-**g Zhao, Liang Liu… in Signal Transduction and Targeted Therapy (2024)

Article

Correction: M⁷G modification of FTH1 and pri-miR-26a regulates ferroptosis and chemotherapy resistance in osteosarcoma

Mingyu He, Yang Wang, Jiajie **e, Jiaying Pu, Zhihua Shen, Ao Wang, Tao Li… in Oncogene (2024)

Article

RIOK3 sustains colorectal cancer cell survival under glucose deprivation via an HSP90α-dependent pathway

Glucose oxidation via the pentose phosphate pathway serves as the primary cellular mechanism for generating nicotinamide adenine dinucleotide phosphate (NADPH). The central regions of solid tumors typically ex...

Nan Zhang, Lu Dong, Tingting Ning, Feng Du, Mengran Zhao, Junxuan Xu… in Oncogenesis (2024)

Article

Neddylation is a novel therapeutic target for lupus by regulating double negative T cell homeostasis

Systemic lupus erythematosus (SLE), a severe autoimmune disorder, is characterized by systemic inflammatory response, autoantibody accumulation and damage to organs. The dysregulation of double-negative (DN) T...

Yun Zhang, Lijun Du, Chenxi Wang… in Signal Transduction and Targeted Therapy (2024)

Article

Camouflaging attenuated Salmonella by cryo-shocked macrophages for tumor-targeted therapy

Live bacteria-mediated antitumor therapies mark a pivotal point in cancer immunotherapy. However, the difficulty in reconciling the safety and efficacy of bacterial therapies has limited their application. Imp...

Leyang Wu, Zengzheng Du, Lin Li, Liyuan Qiao… in Signal Transduction and Targeted Therapy (2024)

Article

A cyclin D1 intrinsically disordered domain accesses modified histone motifs to govern gene transcription

The essential G₁-cyclin, CCND1, is frequently overexpressed in cancer, contributing to tumorigenesis by driving cell-cycle progression. D-type cyclins are rate-limiting regulators of G₁-S progression in mammalian...

Xuanmao Jiao, Gabriele Di Sante, Mathew C. Casimiro, Agnes Tantos… in Oncogenesis (2024)

Article

Josephin domain containing 2 (JOSD2) promotes lung cancer by inhibiting LKB1 (Liver kinase B1) activity

Non-small cell lung cancer (NSCLC) ranks as one of the leading causes of cancer-related deaths worldwide. Despite the prominence and effectiveness of kinase-target therapies in NSCLC treatment, these drugs are...

Tao Yuan, Chenming Zeng, Jiawei Liu… in Signal Transduction and Targeted Therapy (2024)

Article

Trogocytosis of CAR molecule regulates CAR-T cell dysfunction and tumor antigen escape

Chimeric antigen receptor (CAR) T-cell therapy has demonstrated clinical response in treating both hematologic malignancies and solid tumors. Although instances of rapid tumor remissions have been observed in ...

You Zhai, Yicong Du, Guanzhang Li, Mingchen Yu… in Signal Transduction and Targeted Therapy (2023)