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Article
Open AccessAdjusting heterogeneous ascertainment bias for genetic association analysis with extended families
In family-based association analysis, each family is typically ascertained from a single proband, which renders the effects of ascertainment bias heterogeneous among family members. This is contrary to case–co...
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Article
Assessment of Alzheimer’s disease case–control associations using family-based methods
The genetics of Alzheimer’s disease (AD) is heterogeneous and remains only ill-defined. We have recently created a freely available and continuously updated online database (AlzGene; http://www...
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Article
Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database
The past decade has witnessed hundreds of reports declaring or refuting genetic association with putative Alzheimer disease susceptibility genes. This wealth of information has become increasingly difficult to...