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    Enhanced radiation damage of tumor vasculature by mTOR inhibitors

    It is known that radiation activates the phosphoinositol-3 kinase (PI3K)/Akt pathway and that inhibition of PI3K or Akt sensitizes tumor vasculature to radiotherapy. Mammalian target of rapamycin (mTOR) is a d...

    Eric T Shinohara, Carolyn Cao, Ken Niermann, Yi Mu, Fenghua Zeng… in Oncogene (2005)