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Phosphodiesterase 8 (PDE8): Distribution and Cellular Expression and Association with Alzheimer’s Disease

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  1. Article

    Correction to: Gas6 Promotes Microglia Efferocytosis and Suppresses Inflammation Through Activating Axl/Rac1 Signaling in Subarachnoid Hemorrhage Mice

    Junjia Tang, Yichao **, Feng Jia, Tao Lv, Anatol Manaenko in Translational Stroke Research (2024)

  2. Article

    Correction to: (+)-Catechin Alleviates CCI-Induced Neuropathic Pain in Rats by Modulating the IL34/CSFIR Axis and Attenuating the Schwann Cell-Macrophage Cascade Response in the DRG

    Bei **g, Zhen-ni Chen, Wai-mei Si, Jia-ji Zhao, Guo-** Zhao in Molecular Neurobiology (2024)

  3. Article

    Open Access

    Presenilin2 D439A Mutation Induces Dysfunction of Mitochondrial Fusion/Fission Dynamics and Abnormal Regulation of GTPase Activity

    Alzheimer’s disease (AD) is an age-related progressive neurodegenerative disease, and approximately 10% of AD cases are early-onset familial AD (EOFAD), which is mainly linked to point mutations in genes encod...

    Chenhao Gao, Junkui Shang, Zhengyu Sun, Mingrong **a, Dandan Gao in Molecular Neurobiology (2024)

  4. Article

    Open Access

    Esketamine Prevents Postoperative Emotional and Cognitive Dysfunction by Suppressing Microglial M1 Polarization and Regulating the BDNF-TrkB Pathway in Ageing Rats with Preoperative Sleep Disturbance

    Postoperative depression (POD) and postoperative cognitive dysfunction (POCD) have placed heavy burden on patients’ physical and mental health in recent years. Sleep disturbance before surgery is a common phen...

    Yuxin Wen, Jiawen Xu, Jiahong Shen, Zili Tang, Shuxin Li in Molecular Neurobiology (2024)

  5. Article

    Open Access

    The Association Between Branched-Chain Amino Acid Concentrations and the Risk of Autism Spectrum Disorder in Preschool-Aged Children

    Several studies have linked branched-chain amino acid (BCAA) metabolism disorders with autism spectrum disorder (ASD), but the results have been inconsistent. The purpose of this study was to explore the assoc...

    Qi Gao, Dan Bi, Bingbing Li, Min Ni, Dizhou Pang, **an Li in Molecular Neurobiology (2024)

  6. Article

    Open Access

    Neutralizing RGMa with Elezanumab Promotes Cerebroprotection and Recovery in Rabbit Middle Cerebral Artery Occlusion

    Repulsive guidance molecule A (RGMa) is an inhibitor of neuronal growth and survival which is upregulated in the damaged central nervous system following acute spinal cord injury (SCI), traumatic brain injury,...

    Peer B. Jacobson, Andrea Mothe, Aharon Levy in Translational Stroke Research (2024)

  7. Article

    Open Access

    Single-Cell Transcriptome Reveals Cell Type–Specific Molecular Pathology in a 2VO Cerebral Ischemic Mouse Model

    Post-ischemia memory impairment is a major sequela in cerebral ischemia patients. However, cell type–specific molecular pathology in the hippocampus after ischemia is poorly understood. In this study, we adopt...

    Qian Zhang, Zhong Xu, Jian-Feng Guo, Shang-Hang Shen in Molecular Neurobiology (2024)

  8. Article

    Open Access

    HCMV IE1/IE1mut Therapeutic Vaccine Induces Tumor Regression via Intratumoral Tertiary Lymphoid Structure Formation and Peripheral Immunity Activation in Glioblastoma Multiforme

    Glioblastoma multiforme (GBM), a highly malignant invasive brain tumor, is associated with poor prognosis and survival and lacks an effective cure. High expression of the human cytomegalovirus (HCMV) immediate...

    **aoli Yang, Shasha Jiang, Fengjun Liu, Zonghui Li, Wenxuan Liu in Molecular Neurobiology (2024)

  9. Article

    Correction: HDAC1 Promotes Mitochondrial Pathway Apoptosis and Inhibits the Endoplasmic Reticulum Stress Response in High Glucose-Treated Schwann Cells via Decreased U4 Spliceosomal RNA

    Tingting **, Ziming Wang, Fan Fan, Wandi Wei, Chenming Zhou in Neurochemical Research (2024)

  10. Article

    Open Access

    Improved prevention and treatment strategies for differentiation syndrome contribute to reducing early mortality in patients with acute promyelocytic leukemia

    Qian Wu, **aofei Yang, **gren Zhang, Mengxing Xue, Xueqing Dou in Blood Cancer Journal (2024)

  11. Article

    Open Access

    The dual role of FSP1 in programmed cell death: resisting ferroptosis in the cell membrane and promoting necroptosis in the nucleus of THP-1 cells

    Acute monocytic leukemia-M5 (AML-M5) remains a challenging disease due to its high morbidity and poor prognosis. In addition to the evidence mentioned earlier, several studies have shown that programmed cell d...

    **aoqian Tan, Yinling He, Panpan Yu, Yunong Deng, Zhongcheng **e in Molecular Medicine (2024)

  12. Article

    Open Access

    Antibody targeting of anaerobic bacteria warms cold tumors and improves the abscopal effect of radiotherapy

    The combination of immune checkpoint inhibitors with radiotherapy can enhance the immunomodulation by RT and reduce the growth of distant unirradiated tumors (abscopal effect); however, the results are still n...

    WeiZhou Wang, YunXue Zheng, ZhouXue Wu, Min Wu in Journal of Translational Medicine (2024)

  13. Article

    Open Access

    Retraction Note: LncRNA LINC00337 sponges mir-1285-3p to promote proliferation and metastasis of lung adenocarcinoma cells by upregulating YTHDF1

    Ru-nan Zhang, Dong-mei Wu, Li-** Wu, Guo-wei Gao in Cancer Cell International (2024)

  14. Article

    Open Access

    The role of NAD-dependent deacetylase sirtuin-2 in liver metabolic stress through regulating pyruvate kinase M2 ubiquitination

    NAD-dependent deacetylase Sirt2 is involved in mammalian metabolic activities, matching energy demand with energy production and expenditure, and is relevant to a variety of metabolic diseases. Here, we constr...

    **gru Guo, Junshu Nie, Dongni Li, Huaixiu Zhang in Journal of Translational Medicine (2024)

  15. Article

    Open Access

    Intricate effects of post-translational modifications in liver cancer: mechanisms to clinical applications

    Liver cancer is a significant global health challenge, with hepatocellular carcinoma (HCC) being the most prevalent form, characterized by high incidence and mortality rates. Despite advances in targeted thera...

    Yu Zhang, Weihao Xu, Chuanhui Peng, Shenli Ren in Journal of Translational Medicine (2024)

  16. Article

    Open Access

    Carbon-ion radiotherapy alone vs. standard dose photon radiation with carbon-ion radiotherapy boost for high-grade gliomas: a retrospective study

    This study aimed to compare the survival outcome and side effects in patients with primary high-grade glioma (HGG) who received carbon ion radiotherapy (CIRT) alone or as a boost strategy after photon radiatio...

    **aoJun Li, YanShan Zhang, YanCheng Ye, SuQing Tian, TingChao Hu, HongYu Chai in BMC Cancer (2024)

  17. Article

    Open Access

    Investigating distinct clinical features and constructing a nomogram model for survival probability in adults with cerebellar high-grade gliomas

    The clinical features of cerebellar high-grade gliomas (cHGGs) in adults have not been thoroughly explored. This large-scale, population-based study aimed to comprehensively outline these traits and construct ...

    Tao Chang, Rui Zhang, Jiahao Gan, Yuan Yang, Yanhui Liu, Yan Ju, **aodong Niu in BMC Cancer (2024)

  18. Article

    Open Access

    Intelligent ankle–foot prosthesis based on human structure and motion bionics

    The ankle–foot prosthesis aims to compensate for the missing motor functions by fitting the motion characteristics of the human ankle, which contributes to enabling the lower-limb amputees to take care of them...

    Baoyu Li, Guanghua Xu, Zhicheng Teng in Journal of NeuroEngineering and Rehabilita… (2024)

  19. Article

    Open Access

    Integrative metagenomic, transcriptomic, and proteomic analysis reveal the microbiota-host interplay in early-stage lung adenocarcinoma among non-smokers

    The incidence of early-stage lung adenocarcinoma (ES-LUAD) is steadily increasing among non-smokers. Previous research has identified dysbiosis in the gut microbiota of patients with lung cancer. However, the ...

    Yaohui Sun, Zhiming Gan, **ao** Wang, Jian Liu in Journal of Translational Medicine (2024)

  20. Article

    Open Access

    Gut Microbiota in Primary Osteoporosis: a Systematic Review

    The link between gut microbiota (GM) and primary osteoporosis has garnered substantial attention. In this study, we conducted a systematic review encompassing 10 studies that employed high-throughput sequencin...

    Jiangxun Ji, Feihong Cai, Chunchun Yuan, Chen Huang, Haitao Zhang in Phenomics (2024)

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