5 Result(s)

Article

Frequent SLC35A2 brain mosaicism in mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy (MOGHE)

Focal malformations of cortical development (MCD) are linked to somatic brain mutations occurring during neurodevelopment. Mild malformation of cortical development with oligodendroglial hyperplasia in epileps...

Thomas Bonduelle, Till Hartlieb, Sara Baldassari… in Acta Neuropathologica Communications (2021)

Article

The specific DNA methylation landscape in focal cortical dysplasia ILAE type 3D

Focal Cortical Dysplasia (FCD) is a frequent cause of drug-resistant focal epilepsy in children and young adults. The international FCD classifications of 2011 and 2022 have identified several clinico-patholog...

Dan-Dan Wang, Mitali Katoch, Samir Jabari… in Acta Neuropathologica Communications (2023)

Article

D-galactose Supplementation for the Treatment of Mild Malformation of Cortical Development with Oligodendroglial Hyperplasia in Epilepsy (MOGHE): A Pilot Trial of Precision Medicine After Epilepsy Surgery

MOGHE is defined as mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy. Approximately half of the patients with histopathologically confirmed MOGHE carry a brain somatic va...

Ángel Aledo-Serrano, Adrián Valls-Carbó, Christina D. Fenger… in Neurotherapeutics (2023)

Article

Deep histopathology genotype–phenotype analysis of focal cortical dysplasia type II differentiates between the GATOR1-altered autophagocytic subtype IIa and MTOR-altered migration deficient subtype IIb

Focal cortical dysplasia type II (FCDII) is the most common cause of drug-resistant focal epilepsy in children. Herein, we performed a deep histopathology-based genotype–phenotype analysis to further elucidate...

Jonas Honke, Lucas Hoffmann, Roland Coras… in Acta Neuropathologica Communications (2023)

Article

Correction to: The specific DNA methylation landscape in focal cortical dysplasia ILAE type 3D

Dan‑Dan Wang, Mitali Katoch, Samir Jabari… in Acta Neuropathologica Communications (2024)