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Article
Open AccessTERT promoter mutations in gliomas, genetic associations and clinico-pathological correlations
The role of telomerase reverse transcriptase (TERT) in gliomagenesis has been recently further strengthened by the frequent occurrence of TERT promoter mutations (TERTp-mut) in gliomas and evidence that the TERT ...
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Article
Ongoing and prolonged response in adult low-grade gliomas treated with radiotherapy
The aim of the present study was to evaluate the impact of first-line radiotherapy on low-grade gliomas (LGGs) growth kinetics. The mean tumor diameter (MTD) of 39 LGGs was retrospectively measured on serial ...
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Article
Open AccessInterleukin-6 gene amplification and shortened survival in glioblastoma patients
Interleukin-6 (IL-6) is known to promote tumour growth and survival. We evaluated IL-6 gene amplification in tumours from 53 glioma patients using fluorescence in situ hybridisation. Amplification events were det...
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Article
Multidrug Resistance-Associated Protein MRP1 Expression in Human Gliomas: Chemosensitization to Vincristine and Etoposide by Indomethacin in Human Glioma Cell Lines Overexpressing MRP1
The 190 kDa multidrug resistance protein MRP1 is likely to be involved in the multidrug resistance phenotype of human gliomas. MRP1 expression was evaluated in surgical tumor samples from 17 patients with glio...
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Article
Intravascular malignant lymphomatosis
Intravascular malignant lymphomatosis is a rare and probably often overlooked disease characterised by massive intravascular proliferation of lymphoid cells, usually with a poor prognosis. CT and MRI appearanc...
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Article
Radiographic findings in 37 cases of primary CNS lymphoma in immunocompetent patients
Because of the increasing incidence of primary central nervous system lymphoma (PCNSL), it is essential to recognize this disease in order to start appropriate treatment. We present the characteristic CT and ...
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Article
Benign Recurrence of a Cerebellar Pilocytic Astrocytoma 45 Years After Gross Total Resection
¶ Objective and Importance. Cerebellar pilocytic astrocytomas are common benign tumours of childhood and mostly easy to treat because of their location and conformation. Nevertheless, unpredictable recurrence as ...
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Article
Treatment of Meningeal Gliomatosis
To evaluate whether vigorous treatment is beneficial for patients with meningeal gliomatosis (MG) we reviewed the case records of 20 consecutive patients treated for a symptomatic MG in our center. All receive...
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Article
High-intensity lesion on T1-weighted MR images in neurofibromatosis type 1: a case of premalignant lesion
We report a patient with NF1, who was followed up because of an optic glioma and one enhancing lesion presumed to be a pilocytic astrocytoma. T1- and T2-weighted MR images showed also a hyperintense periventri...
