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Article
LKB1 inhibits HPV-associated cancer progression by targeting cellular metabolism
Liver kinase B1 (LKB1) is mutationally inactivated in Peutz–Jeghers syndrome and in a variety of cancers including human papillomavirus (HPV)-caused cervical cancer. However, the significance of LKB1 mutations...
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Article
LKB1 reduces ROS-mediated cell damage via activation of p38
Liver kinase B1 (LKB1, also known as serine/threonine kinase 11, STK11) is a tumor suppressor mutated in Peutz–Jeghers syndrome and in a variety of sporadic cancers. Herein, we demonstrate that LKB1 controls t...
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Article
Open AccessPiperlongumine induces autophagy by targeting p38 signaling
Piperlongumine (PL), a natural product isolated from the plant species Piper longum L., can selectively induce apoptotic cell death in cancer cells by targeting the stress response to reactive oxygen species (...