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  1. No Access

    Article

    Amino acid intake strategies define pluripotent cell states

    Mammalian preimplantation development is associated with marked metabolic robustness, and embryos can develop under a wide variety of nutrient conditions, including even the complete absence of soluble amino a...

    Pavlina K. Todorova, Benjamin T. Jackson, Vidur Garg, Katrina I. Paras… in Nature Metabolism (2024)

  2. No Access

    Article

    Dynamic network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer gene regulatory activity during cell state transitions

    Comprehensive enhancer discovery is challenging because most enhancers, especially those contributing to complex diseases, have weak effects on gene expression. Our gene regulatory network modeling identified ...

    Renhe Luo, Jielin Yan, ** Woo Oh, Wang **, Dustin Shigaki, Wilfred Wong… in Nature Genetics (2023)

  3. No Access

    Article

    Effective breast cancer combination therapy targeting BACH1 and mitochondrial metabolism

    Mitochondrial metabolism is an attractive target for cancer therapy1,2. Reprogramming metabolic pathways could improve the ability of metabolic inhibitors to suppress cancers with limited treatment options, such ...

    Jiyoung Lee, Ali E. Yesilkanal, Joseph P. Wynne, Casey Frankenberger, Juan Liu… in Nature (2019)