3,096 Result(s)

Article

Correction: A positive feedback inhibition of isocitrate dehydrogenase 3β on paired-box gene 6 promotes Alzheimer-like pathology

**n Wang, Qian Liu, Hai-tao Yu, Jia-zhao **e… in Signal Transduction and Targeted Therapy (2024)

Article

SHR-A1811 (antibody-drug conjugate) in advanced HER2-mutant non-small cell lung cancer: a multicenter, open-label, phase 1/2 study

A dose-escalation and expansion, phase 1/2 study (ClinicalTrials.gov, NCT04818333) was conducted to assess the novel antibody-drug conjugate SHR-A1811 in pretreated HER2-altered advanced non-small cell lung ca...

Ziming Li, Zhengbo Song, Wei Hong, Nong Yang… in Signal Transduction and Targeted Therapy (2024)

Article

Targeting CD73 limits tumor progression and enhances anti-tumor activity of anti-PD-1 therapy in intrahepatic cholangiocarcinoma

Patients with intrahepatic cholangiocarcinoma (iCCA) respond poorly to immune checkpoint blockades (ICBs). In this study, we aimed to dissect the potential mechanisms underlying poor response to ICBs and explo...

Bao-Ye Sun, Dai Zhang, Wei Gan, **g-Fang Wu… in Journal of Cancer Research and Clinical On… (2024)

Article

Correction: A CT based radiomics analysis to predict the CN0 status of thyroid papillary carcinoma: a two- center study

Zongbao Li, Yifan Zhong, Yan Lv, Jianzhong Zheng, Yu Hu, Yanyan Yang… in Cancer Imaging (2024)

Article

Causal inference of the effect of blood proteome on the risk of head and neck cancer: two-sample Mendelian randomization

Early diagnosis of head and neck cancer can improve therapeutic outcomes but remains a challenge. The blood proteome can comprise a key source of biomarkers that enable the early diagnosis and precision medici...

Zhen Wang, Jianhao Wu in Discover Oncology (2024)

Article

Surgical outcomes of major vascular resection for retroperitoneal liposarcoma from a high‑volume sarcoma center: a propensity score matching analysis

Radical resection of retroperitoneal liposarcoma (RLPS) may necessitate vascular resection and reconstruction. The study was conducted to assess surgical outcomes of surgery for RLPS with major vascular involv...

Guoqiang Xue, **aopeng Wang, Bonan Liu… in Journal of Cancer Research and Clinical On… (2024)

Article

Targeting the PI3K/AKT/mTOR pathway offer a promising therapeutic strategy for cholangiocarcinoma patients with high doublecortin-like kinase 1 expression

Cholangiocarcinoma (CCA), characterized by high heterogeneity and extreme malignancy, has a poor prognosis. Doublecortin-like kinase 1 (DCLK1) promotes a variety of malignant cancers in their progression. Targ...

Ziwei Liang, Yang Ge, Jianjian Li… in Journal of Cancer Research and Clinical On… (2024)

Article

Effects of the subtypes of apolipoprotein E on immune inhibition and prognosis in patients with Hepatocellular Carcinoma

To investigate whether prognosis of patients with hepatocellular carcinoma (HCC) is affected by the abundance and subgroups of myeloid-derived suppressor cells (MDSCs) as well as subtypes and expression of apo...

Bowen Gao, Peiyun Zhou, Li Wang, Zhutao Wang… in Journal of Cancer Research and Clinical On… (2024)

Article

A deep learning-driven discovery of berberine derivatives as novel antibacterial against multidrug-resistant Helicobacter pylori

Helicobacter pylori (H. pylori) is currently recognized as the primary carcinogenic pathogen associated with gastric tumorigenesis, and its high prevalence and resistance make it difficult to tackle. A graph neur...

**xi Guo, **aosa Zhao, ** Lu, Li** Zhao… in Signal Transduction and Targeted Therapy (2024)

Article

Efficacy and safety of apatinib plus immune checkpoint inhibitors and transarterial chemoembolization for the treatment of advanced hepatocellular carcinoma

The evidence of apatinib plus immune checkpoint inhibitors (ICIs) and transarterial chemoembolization (TACE) for treating advanced hepatocellular carcinoma (HCC) is limited. This study aimed to compare the tre...

Jianfei Wu, Xuefeng Bai, Guodong Yu… in Journal of Cancer Research and Clinical On… (2024)

Article

A cellular senescence-related signature for predicting prognosis, immunotherapy response, and candidate drugs in patients treated with transarterial chemoembolization (TACE)

Cellular senescence is essential to TME development, progression, and remodeling. Few studies have examined cellular senescence in HCC after TACE. Investigating the relationship between cellular senescence, po...

Ning He, Wen**g Zhao, Wenlong Tian, Ying Wu, Jian Xu, Yunyan Lu… in Discover Oncology (2024)

Article

Diagnostic efficiency of intravoxel incoherent motion-based virtual magnetic resonance elastography in pulmonary neoplasms

The aim of the study were as below. (1) To investigate the feasibility of intravoxel incoherent motion (IVIM)-based virtual magnetic resonance elastography (vMRE) to provide quantitative estimates of tissue st...

Shuo Zhang, Yonghao Du, Ting Liang, Xuyin Zhang, Yinxia Guo, Jian Yang… in Cancer Imaging (2024)

Article

Nasopharyngeal amyloidoma: report of three cases and review of the literature

Nasopharyngeal amyloidoma is a rare, locally aggressive tumor that has been reported in the English literature in only 38 cases to date, most of which were in the form of case reports. The present study was ai...

Wangsheng Zuo, Yu Du, Jian-ning Chen in Journal of Cancer Research and Clinical Oncology (2024)

Article

Homoharringtonine may help improve the outcomes of venetoclax and azacitidine in AML1-ETO positive acute myeloid leukemia

T(8;21)(q22;q22.1)/AML1-ETO positive acute myeloid leukemia (AE-AML) is sensitive to conventional chemotherapy with a favorable prognosis. However, recent small case reports suggest the limited effectiveness o...

Zhao Yin, Zurong Yao, Dandan Chen, Yu Zhang… in Journal of Cancer Research and Clinical On… (2024)

Article

Long-term survivals of immune checkpoint inhibitors as neoadjuvant and adjuvant therapy in dMMR/MSI-H colorectal and gastric cancers

The long-term survival benefit of immune checkpoint inhibitors (ICIs) in neoadjuvant and adjuvant settings is unclear for colorectal cancers (CRC) and gastric cancers (GC) with deficiency of mismatch repair (d...

Zhenghang Wang, Siyuan Cheng, Yanhong Yao, Shengde Liu… in Cancer Immunology, Immunotherapy (2024)

Article

Establishment of a nomogram to predict the overall survival of patients with collecting duct renal cell carcinoma

Collecting duct carcinoma (CDC) is a rare histological type of renal cell carcinoma that lacks a prognostic prediction model. In this study, we developed a nomogram to predict the prognosis of CDC patients.

Weixing Jiang, Zuowei Zou, Li Wen in Discover Oncology (2024)

Article

Lathyrol reduces the RCC invasion and incidence of EMT via affecting the expression of AR and SPHK2 in RCC mice

To investigate the effects of Lathyrol on the expression of androgen receptor (AR) and sphingosine kinase 2 (SPHK2) in renal cell carcinoma (RCC) mice and to further explore the mechanism by which Lathyrol inh...

Shengyou Song, Lunwei Tai, Yuqi Xu, Junling Jiang, Lei Zhou… in Discover Oncology (2024)

Article

Small molecule tyrosine kinase inhibitors approved for systemic therapy of advanced hepatocellular carcinoma: recent advances and future perspectives

Liver cancer is the sixth most commonly diagnosed cancer and the third leading cause of cancer death in the world, and hepatocellular carcinoma (HCC) is the most common form of liver cancer. More than half of ...

Jianzhong Liu, Shuai **a, Baoyi Zhang, Dina Mostafa Mohammed… in Discover Oncology (2024)

Article

TCBIR/CD320: a potential therapeutic target upregulated in endothelial cells and associated with immune cell infiltration in liver hepatocellular carcinoma

CD320, which is a transmembrane protein responsible for facilitating the absorption of vitamin B12, plays a key role in this process. However, the relationships between CD320 and immune cell infiltration level...

Shubin Zhang, Zhongyi Jiang, Pusen Wang, Weihao Jiang, Wei Ding… in Discover Oncology (2024)