7 Result(s)
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Article
Jesús Picó
Systems Biology
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Article
Open AccessFlux-dependent graphs for metabolic networks
Cells adapt their metabolic fluxes in response to changes in the environment. We present a framework for the systematic construction of flux-based graphs derived from organism-wide metabolic networks. Our grap...
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Open AccessPFA toolbox: a MATLAB tool for Metabolic Flux Analysis
Metabolic Flux Analysis (MFA) is a methodology that has been successfully applied to estimate metabolic fluxes in living cells. However, traditional frameworks based on this approach have some limitations, par...
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Article
Open AccessMulti-objective optimization framework to obtain model-based guidelines for tuning biological synthetic devices: an adaptive network case
Model based design plays a fundamental role in synthetic biology. Exploiting modularity, i.e. using biological parts and interconnecting them to build new and more complex biological circuits is one of the key...
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Open AccessValidation of an FBA model for Pichia pastoris in chemostat cultures
Constraint-based metabolic models and flux balance analysis (FBA) have been extensively used in the last years to investigate the behavior of cells and also as basis for different industrial applications. In this...
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Article
Open AccessTopology analysis and visualization of Potyvirus protein-protein interaction network
One of the central interests of Virology is the identification of host factors that contribute to virus infection. Despite tremendous efforts, the list of factors identified remains limited. With omics techniq...
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Open AccessValidation of a constraint-based model of Pichia pastoris metabolism under data scarcity
Constraint-based models enable structured cellular representations in which intracellular kinetics are circumvented. These models, combined with experimental data, are useful analytical tools to estimate the s...
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Open AccessA possibilistic framework for constraint-based metabolic flux analysis
Constraint-based models allow the calculation of the metabolic flux states that can be exhibited by cells, standing out as a powerful analytical tool, but they do not determine which of these are likely to be ...
