10 Result(s)
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Article
Jerome Badaut
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Article
Open AccessBlood–brain borders: a proposal to address limitations of historical blood–brain barrier terminology
Many neuroscientists use the term Blood–Brain Barrier (BBB) to emphasize restrictiveness, often equating or reducing the notion of BBB properties to tight junction molecules physically sealing cerebral endothe...
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Open AccessA single mild juvenile TBI in male mice leads to regional brain tissue abnormalities at 12 months of age that correlate with cognitive impairment at the middle age
Traumatic brain injury (TBI) has the highest incidence amongst the pediatric population and its mild severity represents the most frequent cases. Moderate and severe injuries as well as repetitive mild TBI res...
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Open AccessModulating the water channel AQP4 alters miRNA expression, astrocyte connectivity and water diffusion in the rodent brain
Aquaporins (AQPs) facilitate water diffusion through the plasma membrane. Brain aquaporin-4 (AQP4) is present in astrocytes and has critical roles in normal and disease physiology. We previously showed that a ...
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Early to Long-Term Alterations of CNS Barriers After Traumatic Brain Injury: Considerations for Drug Development
Traumatic brain injury (TBI) is one of the leading causes of death and disability, particularly amongst the young and the elderly. The functions of the blood-brain barrier (BBB) and blood-cerebrospinal fluid b...
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Open AccessAquaporin 4: a player in cerebral edema and neuroinflammation
Neuroinflammation is a common pathological event observed in many different brain diseases, frequently associated with blood brain barrier (BBB) dysfunction and followed by cerebral edema. Neuroinflammation is...
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The vascular neural network—a new paradigm in stroke pathophysiology
The neurovascular unit is a key concept in stroke medicine that for many years has been defined as the endothelial cells, neurons and glia surrounding cerebral capillaries. In this Perspectives article, the au...
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Open AccessIncrease of arginase activity in old apolipoprotein-E deficient mice under Western diet associated with changes in neurovascular unit
Aging and atherosclerosis are well-recognized risk factors for cardiac and neurovascular diseases. The Apolipoprotein E deficient (ApoE−/−) mouse on a high-fat diet is a classical model of atherosclerosis, cha...
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Aquaporins in the brain: from aqueduct to “multi-duct”
The aquaporin channel family was first considered as a family of water channels, however it is now clear that some of these channels are also permeable to small solutes such glycerol, urea and monocarboxylates...
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Temporal and Regional Evolution of Aquaporin-4 Expression and Magnetic Resonance Imaging in a Rat Pup Model of Neonatal Stroke
Edema formation can be observed using magnetic resonance imaging (MRI) in patients with stroke. Recent studies have shown that aquaporin-4 (AQP4), a water channel, is induced early after stroke and potentially...
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Albumin Reduces Blood-Brain Barrier Permeability But Does Not Alter Infarct Size in a Rat Model of Neonatal Stroke
Human serum albumin therapy confers neurobehavioral and histopathologic neuroprotection in adult stroke models. We investigated whether albumin might also be neuroprotective in ischemic brain injury using a tr...
