10 Result(s)
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Article
Jacques Ohayon
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Article
Open AccessPrecision delivery of liquid therapy into the arterial wall for the treatment of peripheral arterial disease
Perfusion catheters have recently emerged as a novel approach to deliver liquid anti-proliferative agents into flow obstructed arterial segments. The purpose of this study was to determine the impact of lumina...
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Influence of Collaterals on True FFR Prediction for a Left Main Stenosis with Concomitant Lesions: An In Vitro Study
With the aim of assisting interventional cardiologists during decision making for revascularization, reduced-order (0D) approaches have been developed to predict the true fractional flow reserve (FFRTrue) of indi...
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Biomechanics of Atherosclerotic Coronary Plaque: Site, Stability and In Vivo Elasticity Modeling
Coronary atheroma develop in local sites that are widely variable among patients and are considerably variable in their vulnerability for rupture. This article summarizes studies conducted by our collaborative...
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Elucidating atherosclerotic vulnerable plaque rupture by modeling cross substitution of ApoE−/− mouse and human plaque components stiffnesses
The structure of mouse atherosclerotic lesions may differ from that of humans, and mouse atherosclerotic plaques do not rupture except in some specific locations such as the brachiocephalic artery. Recently, o...
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Open AccessThe feasibility of 350 micron spatial resolution coronary MRA at 3T in humans
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Open AccessCombined imaging, computational and histological analysis of a ruptured carotid plaque: A patient-specific analysis
Rupture of carotid plaques is an important cause of cerebrovascular events. Several factors, including wall shear stress (WSS), plaque morphology and peak cap stress, have been associated with plaque vulnerabi...
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High-Affinity αvβ3 Integrin Targeted Optical Probe as a New Imaging Biomarker for Early Atherosclerosis: Initial Studies in Watanabe Rabbits
A newly developed synthetic αvβ3 integrin targeted optical probe (ITOP) has been demonstrated to target cancer cells, in vivo. Compared to the commercially available cyclic peptide c[RGDfv], this optical probe ha...
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An Integrative Model of the Self-Sustained Oscillating Contractions of Cardiac Myocytes
Computational cell models appear as necessary tools for handling the complexity of intracellular cell dynamics, especially calcium dynamics. However, while oscillating intracellular calcium oscillations are we...
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Article
Computation of Adherent Cell Elasticity for Critical Cell-Bead Geometry in Magnetic Twisting Experiments
Quantification of the cell elastic modulus is a central issue of micromanipulation techniques used to analyze the mechanical properties of living adherent cells. In magnetic twisting cytometry (MTC), magnetic ...
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Article
Transmission of Mechanical Stresses within the Cytoskeleton of Adherent Cells: A Theoretical Analysis Based on a Multi-Component Cell Model
How environmental mechanical forces affect cellular functions is a central problem in cell biology. Theoretical models of cellular biomechanics provide relevant tools for understanding how the contributions of...
