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  1. Article

    Mortality predictors in patients with COVID-19 pneumonia: a machine learning approach using eXtreme Gradient Boosting model

    Recently, global health has seen an increase in demand for assistance as a result of the COVID-19 pandemic. This has prompted many researchers to conduct different studies looking for variables that are associ...

    N. Casillas, A. M. Torres, M. Moret, A. Gómez… in Internal and Emergency Medicine (2022)

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    Article

    Prevention of venous thromboembolism in hematologic neoplasms: an expert consensus from SEHH–SETH

    Venous thromboembolism (VTE) is a serious complication in hematologic neoplasms, so finding adequate prevention strategies is an urgent requirement. However, prospective studies with large enough cohorts are s...

    J. R. Gonzalez-Porras, J. Mateo, V. Gonzalez-Calle… in Clinical and Translational Oncology (2022)

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    Article

    An Adaptive Study to Determine the Optimal Dose of the Tablet Formulation of the PARP Inhibitor Olaparib

    Olaparib is poorly soluble, requiring advanced drug delivery technologies for adequate bioavailability. Sixteen capsules/day are required for the approved 400 mg twice-daily dose; a tablet formulation was deve...

    J. Mateo, V. Moreno, A. Gupta, S. B. Kaye, E. Dean, M. R. Middleton… in Targeted Oncology (2016)

  4. Article

    Open Access

    Economic Analysis of Thrombo inCode, a Clinical–Genetic Function for Assessing the Risk of Venous Thromboembolism

    Patients with venous thromboembolism (VTE) commonly have an underlying genetic predisposition. However, genetic tests nowadays in use have very low sensitivity for identifying subjects at risk of VTE. Thrombo ...

    C. Rubio-Terrés, J. M. Soria, P. E. Morange… in Applied Health Economics and Health Policy (2015)

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  5. Article

    Open Access

    A first-in-human study of the anti-α5β1 integrin monoclonal antibody PF-04605412 administered intravenously to patients with advanced solid tumors

    A first-in-human clinical trial of a fully human, Fc-engineered IgG1 monoclonal antibody targeting integrin α5β1 was conducted to evaluate tolerability, maximum tolerated dose, pharmacokinetics, pharmacodynami...

    J. Mateo, J. Berlin, J. S. de Bono, R. B. Cohen… in Cancer Chemotherapy and Pharmacology (2014)

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    Article

    Gradients de PCO2 : un reflet fiable de la perfusion macroet microcirculatoire

    L’augmentation des gradients veinoartériel et tissuartériel en CO2 (Pv-aCO2 et Pt-aCO2) est un phénomène régulièrement retrouvé dans des travaux expérimentaux ou des études cliniques sur les défaillances circulat...

    F. Vallée, J. Mateo, B. Vallet, D. Payen in Réanimation (2011)

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    Article

    Silibinin inhibits hypoxia-inducible factor-1α and mTOR/p70S6K/4E-BP1 signalling pathway in human cervical and hepatoma cancer cells: implications for anticancer therapy

    The hypoxia-inducible factor 1 (HIF-1) plays a critical role for tumour adaptation to microenvironmental hypoxia, and represents an appealing chemotherapeutic target. Silibinin is a nontoxic flavonoid reported...

    P García-Maceira, J Mateo in Oncogene (2009)

  8. Article

    Physical training decreases plasma thrombomodulin in Type I and Type II diabetic patients

    Aims/hypothesis. Endothelial damage is an early step in the pathogenesis of atherosclerosis and its improvement through physical training can contribute to the known reduction of cardiovascular r...

    M. Rigla, J. Fontcuberta, J. Mateo, A. Caixàs, J. M. Pou, A. de Leiva… in Diabetologia (2001)

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    Article

    Severe bleeding in a patient with spontaneous factor VIII inhibitor and acute exacerbation of chronic pancreatitis

    C. Martínez, J. Mateo, J. Fontcuberta, M. Pérez, E. Quintana… in Intensive Care Medicine (1996)

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    Article

    Acquired factor VIII inhibitor preceding chronic lymphocytic leukemia

    An acquired factor VIII inhibitor was found in an 82-year-old woman who presented with numerous spontaneously appearing ecchymoses. Coagulation studies revealed the presence of a prolonged activated partial th...

    J. Mateo, R. Martino, M. Borrell, M. Garí, F. Casas, J. Fontcuberta in Annals of Hematology (1993)