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Article
Stimulated Brillouin scattering from multi-GHz-guided acoustic phonons in nanostructured photonic crystal fibres
Wavelength-scale periodic microstructuring dramatically alters the optical properties of materials. An example is glass photonic crystal fibre1 (PCF), which guides light by means of a lattice of hollow micro/nano...
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Article
Open AccessTranscriptional repression and DNA loo** associated with a novel regulatory element in the final exon of the lymphotoxin-β gene
Transcriptional regulation has a critical role in the coordinate and context-specific expression of a cluster of genes encoding members of the tumour necrosis factor (TNF) superfamily found at chromosome 6p21,...
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Article
Open AccessA functional AT/G polymorphism in the 5′-untranslated region of SETDB2 in the IgE locus on human chromosome 13q14
The immunoglobulin E (IgE)-associated locus on human chromosome 13q14 influencing asthma-related traits contains the genes PHF11 and SETDB2. SETDB2 is located in the same linkage disequilibrium region as PHF11 an...
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Article
Open AccessErratum: A functional AT/G polymorphism in the 5′-untranslated region of SETDB2 in the IgE locus on human chromosome 13q14
Correction to: Genes and Immunity (2015) 16, 488–494; doi:10.1038/gene.2015.36; published online 17 September 2015 Updated online 12 May 2016: This article was originally published under a CC BY-NC-SA 4.0 lice...
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Article
Open AccessInvestigation of a possible extended risk haplotype in the IL23R region associated with ankylosing spondylitis
The IL23R region on chromosome 1 exhibits complex associations with ankylosing spondylitis (AS). We used publicly available epigenomic information and historical genetic association data to identify a putative re...
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Article
Open AccessUnique transcriptome signatures and GM-CSF expression in lymphocytes from patients with spondyloarthritis
Spondyloarthritis encompasses a group of common inflammatory diseases thought to be driven by IL-17A-secreting type-17 lymphocytes. Here we show increased numbers of GM-CSF-producing CD4 and CD8 lymphocytes in...
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Article
Open AccessA disease-associated gene desert directs macrophage inflammation through ETS2
Increasing rates of autoimmune and inflammatory disease present a burgeoning threat to human health1. This is compounded by the limited efficacy of available treatments1 and high failure rates during drug develop...