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Article
Evidence against dopamine D1/D2 receptor heteromers
Hetero-oligomers of G-protein-coupled receptors have become the subject of intense investigation, because their purported potential to manifest signaling and pharmacological properties that differ from the com...
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Article
Open AccessThe atypical antidepressant and neurorestorative agent tianeptine is a μ-opioid receptor agonist
Current pharmacological treatments of depression and related disorders suffer from major problems, such as a low rate of response, slow onset of therapeutic effects, loss of efficacy over time and serious side...
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Article
Amphetamine-induced behavior requires CaMKII-dependent dopamine transporter phosphorylation
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Article
Increasing dopamine D2 receptor expression in the adult nucleus accumbens enhances motivation
A decrease in dopamine D2 receptor (D2R) binding in the striatum is one of the most common findings in disorders that involve a dysregulation of motivation, including obesity, addiction and attention deficit h...
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Article
The membrane raft protein Flotillin-1 is essential in dopamine neurons for amphetamine-induced behavior in Drosophila
The dopamine transporter (DAT) is the primary molecular target responsible for the rewarding properties of the psychostimulants amphetamine (AMPH) and cocaine. AMPH increases extracellular dopamine (DA) by pro...
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Article
Antipsychotic drug mechanisms: links between therapeutic effects, metabolic side effects and the insulin signaling pathway
The exact therapeutic mechanism of action of antipsychotic drugs remains unclear. Recent evidence has shown that second-generation antipsychotic drugs (SGAs) are differentially associated with metabolic side e...