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  1. No Access

    Article

    Antipsychotic drug mechanisms: links between therapeutic effects, metabolic side effects and the insulin signaling pathway

    The exact therapeutic mechanism of action of antipsychotic drugs remains unclear. Recent evidence has shown that second-generation antipsychotic drugs (SGAs) are differentially associated with metabolic side e...

    R R Girgis, J A Javitch, J A Lieberman in Molecular Psychiatry (2008)

  2. No Access

    Article

    The membrane raft protein Flotillin-1 is essential in dopamine neurons for amphetamine-induced behavior in Drosophila

    The dopamine transporter (DAT) is the primary molecular target responsible for the rewarding properties of the psychostimulants amphetamine (AMPH) and cocaine. AMPH increases extracellular dopamine (DA) by pro...

    A B Pizzo, C S Karam, Y Zhang, H Yano, R J Freyberg, D S Karam… in Molecular Psychiatry (2013)

  3. No Access

    Article

    Increasing dopamine D2 receptor expression in the adult nucleus accumbens enhances motivation

    A decrease in dopamine D2 receptor (D2R) binding in the striatum is one of the most common findings in disorders that involve a dysregulation of motivation, including obesity, addiction and attention deficit h...

    P Trifilieff, B Feng, E Urizar, V Winiger, R D Ward, K M Taylor… in Molecular Psychiatry (2013)

  4. No Access

    Article

    Amphetamine-induced behavior requires CaMKII-dependent dopamine transporter phosphorylation

    A B Pizzo, C S Karam, Y Zhang, C L Ma, B D McCabe, J A Javitch in Molecular Psychiatry (2014)

  5. Article

    Open Access

    The atypical antidepressant and neurorestorative agent tianeptine is a μ-opioid receptor agonist

    Current pharmacological treatments of depression and related disorders suffer from major problems, such as a low rate of response, slow onset of therapeutic effects, loss of efficacy over time and serious side...

    M M Gassaway, M-L Rives, A C Kruegel, J A Javitch, D Sames in Translational Psychiatry (2014)

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  6. No Access

    Article

    Evidence against dopamine D1/D2 receptor heteromers

    Hetero-oligomers of G-protein-coupled receptors have become the subject of intense investigation, because their purported potential to manifest signaling and pharmacological properties that differ from the com...

    A L Frederick, H Yano, P Trifilieff, H D Vishwasrao, D Biezonski… in Molecular Psychiatry (2015)