15 Result(s)
within
Article
Hyun** Koo
Life Sciences
-
Article
Open AccessHepatocyte GPCR signaling regulates IRF3 to control hepatic stellate cell transdifferentiation
Interferon Regulatory Factor 3 (IRF3) is a transcription factor that plays a crucial role in the innate immune response by recognizing and responding to foreign antigens. Recently, its roles in sterile conditi...
-
Article
Open AccessMitochondrial stress activates YAP/TAZ through RhoA oxidation to promote liver injury
Yes-associated protein (YAP) and WW domain-containing transcription regulator protein 1 (WWTR1; also known as TAZ) are the main effectors of the Hippo pathway and their dysregulation contributes to diseases in...
-
Article
Open AccessGenome structure and diversity among Cynanchum wilfordii accessions
Cynanchum wilfordii (Cw) and Cynanchum auriculatum (Ca) have long been used in traditional medicine and as functional food in Korea and China, respectively. They have diverse medicinal functions, and many studies...
-
Article
Open AccessIncongruence between dominant commensal donor microbes in recipient feces post fecal transplant and response to anti-PD-1 immunotherapy
To understand inter-individual variability of fecal microbe transplantation (FMT) to enhance anti-PD-1 immunotherapy (IT) for melanoma, we analyzed the data sets from two recent publications with a microbial s...
-
Article
Open AccessImpact of the repurposed drug thonzonium bromide on host oral-gut microbiomes
Drug repurposing is a feasible strategy for the development of novel therapeutic applications. However, its potential use for oral treatments and impact on host microbiota remain underexplored. Here, we assess...
-
Article
Open AccessIndividualized recovery of gut microbial strains post antibiotics
To further understand the impact of antibiotics on the gastrointestinal tract microbial community, the intra-individual recovery pattern of specific microbial strains was determined using metagenomic sequencin...
-
Article
The oral microbiota: dynamic communities and host interactions
The dynamic and polymicrobial oral microbiome is a direct precursor of diseases such as dental caries and periodontitis, two of the most prevalent microbially induced disorders worldwide. Distinct microenviron...
-
Article
Targeting microbial biofilms: current and prospective therapeutic strategies
Biofilms harbour complex structural and biological attributes, such as the presence of an extracellular polymeric matrix, physical and chemical heterogeneity a...
-
Article
Comparative analysis of bacterial community-metagenomics in coastal Gulf of Mexico sediment microcosms following exposure to Macondo oil (MC252)
The indigenous bacterial communities in sediment microcosms from Dauphin Island (DI), Petit Bois Island (PB) and Perdido Pass (PP) of the coastal Gulf of Mexico were compared following treatment with Macondo o...
-
Article
Open AccessGinger and turmeric expressed sequence tags identify signature genes for rhizome identity and development and the biosynthesis of curcuminoids, gingerols and terpenoids
Ginger (Zingiber officinale) and turmeric (Curcuma longa) accumulate important pharmacologically active metabolites at high levels in their rhizomes. Despite their importance, relatively little is known regarding...
-
Article
Increase in the production of β-carotene in recombinant Escherichia coli cultured in a chemically defined medium supplemented with amino acids
Escherichia coli DH5α strain was selected as the recombinant host, and a chemically defined medium supplemented with amino acids was used instead of a complex medium for the efficient production ...
-
Article
Quercetin production from rutin by a thermostable β-rutinosidase from Pyrococcus furiosus
Pyrococcus furiosus β-glucosidase converted rutin to quercetin and rutinose disaccharide with a ratio of 1:1, with no glucose, l-rhamnose, and isoquercitrin, indicating that the enzyme is a β-rut...
-
Article
Open AccessComparison of Monthly Ibandronate Versus Weekly Risedronate in Preference, Convenience, and Bone Turnover Markers in Korean Postmenopausal Osteoporotic Women
Patient preferences, convenience, and bone turnover markers were evaluated for the monthly ibandronate over the weekly risedronate regimen in Korean postmenopausal osteoporotic women. This was a 6-month, prosp...
-
Article
Open AccessInfluences of naturally occurring agents in combination with fluoride on gene expression and structural organization of Streptococcus mutans in biofilms
The association of specific bioactive flavonoids and terpenoids with fluoride can modulate the development of cariogenic biofilms by simultaneously affecting the synthesis of exopolysaccharides (EPS) and acid ...
-
Article
Effect of a New Variety of Apis mellifera Propolis onMutans Streptococci
