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Article
Evidences for B6C3-Tg (APPswe/PSEN1dE9) Double-Transgenic Mice Between 3 and 10 Months as an Age-Related Alzheimer’s Disease Model
Transgenic mouse has shown great advantages in the study of Alzheimer’s disease (AD) and drug screening as AD develops rapidly resent years, while more detail information of these transgenic mice and experienc...
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Article
Three N-Glycosylation Sites of Human Acetylcholinesterase Shares Similar Glycan Composition
Acetylcholinesterase (AChE; EC 3.1.1.7) is a glycoprotein possessing three conserved N-linked glycosylation sites in mammalian species, locating at 296, 381, and 495 residues of the human sequence. Several lines ...
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Article
Selective 14-3-3γ Upregulation Promotes Beclin-1-LC3-Autophagic Influx via β-Catenin Interaction in Starved Neurons In Vitro and In Vivo
Lack of blood or glucose supply is the most common pathological factor in the brain. To cope with such an energy stress, initiating programmed autophagic processes in neurons is required. However, the mechanis...