7 Result(s)
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Article
Harish Nagarajan
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Article
Open AccessCharacterizing acetogenic metabolism using a genome-scale metabolic reconstruction of Clostridium ljungdahlii
The metabolic capabilities of acetogens to ferment a wide range of sugars, to grow autotrophically on H2/CO2, and more importantly on synthesis gas (H2/CO/CO2) make them very attractive candidates as production h...
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Characterization and modelling of interspecies electron transfer mechanisms and microbial community dynamics of a syntrophic association
Syntrophic associations are central to microbial communities and thus have a fundamental role in the global carbon cycle. Despite biochemical approaches describing the physiological activity of these communiti...
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Open AccessGenomic landscapes of Chinese hamster ovary cell lines as revealed by the Cricetulus griseus draft genome
Genome sequences of the Chinese hamster and six Chinese hamster ovary cell lines provide a resource to aid in improving production of recombinant proteins.
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Characterizing the interplay between multiple levels of organization within bacterial sigma factor regulatory networks
Bacteria contain multiple sigma factors, each targeting diverse, but often overlap** sets of promoters, thereby forming a complex network. The layout and deployment of such a sigma factor network directly im...
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The microbiome extends to subepidermal compartments of normal skin
Commensal microbes on the skin surface influence the behaviour of cells below the epidermis. We hypothesized that bacteria or their products exist below the surface epithelium and thus permit physical interact...
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Constraining the metabolic genotype–phenotype relationship using a phylogeny of in silico methods
Our understanding of genotype–phenotype relationships has classically been qualitative, but recent advances are enabling us to overcome conceptual and technolo...
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Open AccessThe genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line
Since 1987, immortalized cells from the ovary of a Chinese hamster have been the workhorse for producing recombinant therapeutics, including monoclonal antibodies, blood factors, hormones, growth factors and e...
