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Article
Open AccessBiased random walk model for the prioritization of drug resistance associated proteins
Multi-drug resistance is the main cause of treatment failure in cancer patients. How to identify molecules underlying drug resistance from multi-omics data remains a great challenge. Here, we introduce a data ...
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Article
Forkhead box C1 promotes colorectal cancer metastasis through transactivating ITGA7 and FGFR4 expression
Metastatic colorectal cancer (CRC) is one of the most common causes of cancer death worldwide; however, the molecular mechanism underlying CRC metastasis remains unknown. Using an integrated approach, we ident...
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Article
Open AccessWhole-genome sequencing reveals novel tandem-duplication hotspots and a prognostic mutational signature in gastric cancer
Genome-wide analysis of genomic signatures might reveal novel mechanisms for gastric cancer (GC) tumorigenesis. Here, we analysis structural variations (SVs) and mutational signatures via whole-genome sequenci...
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Article
Open AccessMEIS2C and MEIS2D promote tumor progression via Wnt/β-catenin and hippo/YAP signaling in hepatocellular carcinoma
MEIS2 has been identified as one of the key transcription factors in the gene regulatory network in the development and pathogenesis of human cancers. Our study aims to identify the regulatory mechanisms of ME...
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Article
Downregulation of TMEM220 promotes tumor progression in Hepatocellular Carcinoma
During the process of long-term carcinogenesis, cells accumulate many mutations. Deregulated genes expression causes profound changes in cell proliferation, which is one of the hallmarks of HCC. A comprehensiv...
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Article
Open AccessIntegrative analysis of chromatin accessibility and transcriptome landscapes in the induction of peritoneal fibrosis by high glucose
Peritoneal fibrosis is the prevailing complication induced by prolonged exposure to high glucose in patients undergoing peritoneal dialysis.