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    Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease

    Defects in dendritic spines are common to several forms of cognitive deficits, including mental retardation and Alzheimer disease. Because mutation of p21-activated kinase (PAK) can lead to mental retardation ...

    Lixia Zhao, Qiu-Lan Ma, Frédéric Calon, Marni E Harris-White… in Nature Neuroscience (2006)

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    Ibuprofen Suppresses Interleukin-1β Induction of Pro-Amyloidogenic α1-Antichymotrypsin to Ameliorate β-Amyloid (Aβ) Pathology in Alzheimer's Models

    Epidemiological and basic research suggests that nonsteroidal anti-inflammatory drugs (NSAIDs) should protect against the most common forms of Alzheimer's disease (AD). Ibuprofen reduces amyloid (Aβ) pathology in...

    Takashi Morihara, Bruce Teter, Fusheng Yang, Giselle P Lim… in Neuropsychopharmacology (2005)

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