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  1. Article

    Open Access

    Components of genetic associations across 2,138 phenotypes in the UK Biobank highlight adipocyte biology

    Population-based biobanks with genomic and dense phenotype data provide opportunities for generating effective therapeutic hypotheses and understanding the genomic role in disease predisposition. To characteri...

    Yosuke Tanigawa, Jiehan Li, Johanne M. Justesen, Heiko Horn in Nature Communications (2019)

  2. No Access

    Article

    A family of transposable elements co-opted into developmental enhancers in the mouse neocortex

    The neocortex is a mammalian-specific structure that is responsible for higher functions such as cognition, emotion and perception. To gain insight into its evolution and the gene regulatory codes that pattern...

    James H. Notwell, Tisha Chung, Whitney Heavner, Gill Bejerano in Nature Communications (2015)

  3. No Access

    Article

    Human-specific loss of regulatory DNA and the evolution of human-specific traits

    A computational survey of the human genome has identified more than 500 human-specific genomic deletions that remove sequences that are highly conserved between chimpanzees and other animals. These are genomic...

    Cory Y. McLean, Philip L. Reno, Alex A. Pollen, Abraham I. Bassan in Nature (2011)

  4. No Access

    Article

    A distal enhancer and an ultraconserved exon are derived from a novel retroposon

    Evidence from vertebrate genome sequences has shown that conserved noncoding regions significantly outnumber coding regions, and that these elements are mostly involved in gene regulation. The origins of these...

    Gill Bejerano, Craig B. Lowe, Nadav Ahituv, Bryan King, Adam Siepel in Nature (2006)