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  1. No Access

    Article

    Brain Isoprenoids Farnesyl Pyrophosphate and Geranylgeranyl Pyrophosphate are Increased in Aged Mice

    The mevalonate/isoprenoids/cholesterol pathway has a fundamental role in the brain. Increasing age could be associated with specific changes in mevalonate downstream products. Other than age differences in bra...

    Gero P. Hooff, W. Gibson Wood, Ji-Hyun Kim, Urule Igbavboa… in Molecular Neurobiology (2012)

  2. Article

    Open Access

    Dried blood spot UHPLC-MS/MS analysis of oseltamivir and oseltamivircarboxylate—a validated assay for the clinic

    The neuraminidase inhibitor oseltamivir (Tamiflu®) is currently the first-line therapy for patients with influenza virus infection. Common analysis of the prodrug and its active metabolite oseltamivircarboxyla...

    Gero P. Hooff, Roland J. W. Meesters… in Analytical and Bioanalytical Chemistry (2011)

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    A rapid and sensitive assay for determining human brain levels of farnesyl-(FPP) and geranylgeranylpyrophosphate (GGPP) and transferase activities using UHPLC–MS/MS

    The isoprenoids farnesyl-(FPP) and geranylgeranylpyrophosphate (FPP and GGPP) are two major lipid intermediates in the mevalonate pathway. They participate in post-translational modification of members of the ...

    Gero P. Hooff, Nina Patel, W. Gibson Wood… in Analytical and Bioanalytical Chemistry (2010)

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    Article

    Modulation of Cholesterol, Farnesylpyrophosphate, and Geranylgeranylpyrophosphate in Neuroblastoma SH-SY5Y-APP695 Cells: Impact on Amyloid Beta-Protein Production

    There is keen interest in the role of the isoprenoids farnesylpyrophosphate (FPP) and geranylgeranylpyrophosphate (GGPP) in protein prenylation and cell function in Alzheimer’s disease (AD). We recently report...

    Gero P. Hooff, Imke Peters, W. Gibson Wood, Walter E. Müller… in Molecular Neurobiology (2010)

  5. No Access

    Article

    Isoprenoid quantitation in human brain tissue: a validated HPLC–fluorescence detection method for endogenous farnesyl- (FPP) and geranylgeranylpyrophosphate (GGPP)

    Farnesyl- and geranylgeranylpyrophosphate (FPP and GGPP) are isoprenoid intermediates in the mevalonate pathway. They play a crucial role in cell survival, growth and differentiation due to their attachment (i...

    Gero P. Hooff, Dietrich A. Volmer, W. Gibson Wood… in Analytical and Bioanalytical Chemistry (2008)