7,344 Result(s)

Article

MiR-425-5p suppression of Crebzf regulates oocyte aging via chromatin modification

Female infertility due to declining oocyte quality with age remains a significant challenge for patients and physicians, despite extensive research efforts. Recent studies suggest that microRNAs (miRNAs), whic...

Kadiliya Jueraitetibaike, Ting Tang, Rujun Ma, Shanmeizi Zhao, Ronghua Wu… in GeroScience (2024)

Article

The ubiquitin-like protein UBTD1 promotes colorectal cancer progression by stabilizing c-Myc to upregulate glycolysis

Dysfunction of the ubiquitin-proteasome system (UPS) is involved in the pathogenesis of various malignancies including colorectal cancer (CRC). Ubiquitin domain containing 1 (UBTD1), a ubiquitin-like protein, ...

Liqin Zhao, Nuoya Yu, Yujia Zhai, Yanan Yang, Yixuan Wang, Yue Yang… in Cell Death & Disease (2024)

Article

Age-related dysregulation of CXCL9/10 in monocytes is linked to impaired innate immune responses in a mouse model of Staphylococcus aureus osteomyelitis

Age-associated impairments in innate immunity are believed to be a causative factor responsible for severe pathogenesis of Staphylococcus aureus (S. aureus) infection in the bone tissue. However, the basis for ag...

Yihuang Lin, Mankai Yang, Chubin Cheng, Jichang Wu… in Cellular and Molecular Life Sciences (2024)

Article

TRAF6 promotes spinal microglial M1 polarization to aggravate neuropathic pain by activating the c-JUN/NF-kB signaling pathway

The neuropathic pain with complex networks of neuroinflammatory activation severely limits clinical therapeutic research. TNF receptor-associated factor 6 (TRAF6) is associated with multiple inflammatory disea...

Yu Zhao, Tiegang Li, Lichun Zhang, Jun Yang, Feng Zhao… in Cell Biology and Toxicology (2024)

Article

Specific Mode Electroacupuncture Stimulation Mediates the Delivery of NGF Across the Hippocampus Blood–Brain Barrier Through p65-VEGFA-TJs to Improve the Cognitive Function of MCAO/R Convalescent Rats

Cognitive impairment frequently presents as a prevalent consequence following stroke, imposing significant burdens on patients, families, and society. The objective of this study was to assess the effectivenes...

Mengyuan Dai, Kecheng Qian, Qinyu Ye, **ding Yang, Lin Gan… in Molecular Neurobiology (2024)

Article

Synergistic induction of mitotic pyroptosis and tumor remission by inhibiting proteasome and WEE family kinases

Mitotic catastrophe (MC), which occurs under dysregulated mitosis, represents a fascinating tactic to specifically eradicate tumor cells. Whether pyroptosis can be a death form of MC remains unknown. Proteasom...

Zhan-Li Chen, Chen **e, Wei Zeng, Rui-Qi Huang… in Signal Transduction and Targeted Therapy (2024)

Article

Structural basis of tethered agonism and G protein coupling of protease-activated receptors

Protease-activated receptors (PARs) are a unique group within the G protein-coupled receptor superfamily, orchestrating cellular responses to extracellular proteases via enzymatic cleavage, which triggers intr...

Jia Guo, Yun-Li Zhou, Yixin Yang, Shimeng Guo, Erli You, **n **e, Yi Jiang… in Cell Research (2024)

Article

Correction: Pyrroloquinoline quinone promotes human mesenchymal stem cell-derived mitochondria to improve premature ovarian insufficiency in mice through the SIRT1/ATM/p53 pathway

Shengjie Liu, Yuanmei Wang, Hanlin Yang, Jun Tan… in Stem Cell Research & Therapy (2024)

Article

Correction to: Exogenous Adenosine Antagonizes Excitatory Amino Acid Toxicity in Primary Astrocytes

Yingjiao Liu, Shifeng Chu, Yaomei Hu, Songwei Yang… in Cellular and Molecular Neurobiology (2024)

Article

CD74 is a functional MIF receptor on activated CD4⁺ T cells

Next to its classical role in MHC II-mediated antigen presentation, CD74 was identified as a high-affinity receptor for macrophage migration inhibitory factor (MIF), a pleiotropic cytokine and major determinan...

Lin Zhang, Iris Woltering, Mathias Holzner… in Cellular and Molecular Life Sciences (2024)

Article

Uncovering the role of ferroptosis in Bietti crystalline dystrophy and potential therapeutic strategies

Bietti crystalline dystrophy (BCD) is an inherited retinal degeneration disease caused by mutations in the CYP4V2 gene. Currently, there is no clinical therapy approach available for BCD patients. Previous resear...

Chang Shen, Qianjie Yang, Kuangqi Chen, Huiling Ma… in Cell Communication and Signaling (2024)

Article

Dexmedetomidine and argon in combination against ferroptosis through tackling TXNIP-mediated oxidative stress in DCD porcine livers

Graft availability from donation after circulatory death (DCD) is significantly limited by ischaemia reperfusion (IR) injury. Effective strategies to mitigate IR injury in DCD grafts are essential to improve g...

Qian Chen, Jiashi Sun, **angfeng Liu, Zhigang Qin, Jieyu Li… in Cell Death Discovery (2024)

Article

LINC01133 promotes pancreatic ductal adenocarcinoma epithelial–mesenchymal transition mediated by SPP1 through binding to Arp3

Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with limited treatment methods. Long non-coding RNAs (lncRNAs) have been found involved in tumorigenic and progression. The present study revealed th...

Yefan Yang, Yuxi Gong, Ying Ding, Shuning Sun, Rumeng Bai… in Cell Death & Disease (2024)

Article

The Role of the Intestinal Flora and Its Derivatives in Neurocognitive Disorders: A Narrative Review from Surgical Perspective

Perioperative neurocognitive dysfunction is a significant concern for population health, impacting postoperative recovery and increasing the financial burden on patients. With an increasing number of surgical ...

Jian Huang, Tian-Shou Qin, Yun Bo, Yu-** Li, Rong-Sheng Liu… in Molecular Neurobiology (2024)

Article

SETD8 inhibits apoptosis and ferroptosis of Ewing’s sarcoma through YBX1/RAC3 axis

Ewing’s sarcoma (ES) represents a rare yet exceedingly aggressive neoplasm that poses a significant health risk to the pediatric and adolescent population. The clinical outcomes for individuals with relapsed o...

Huimou Chen, **g Hu, **lin **ong, Hongling Chen, Qiaofang Liao… in Cell Death & Disease (2024)

Article

Publisher Correction: Restrained Mitf-associated autophagy by Mulberroside A ameliorates osteoclastogenesis and counteracts OVX-Induced osteoporosis in mice

Hong Xue, Zhenhua Feng, Putao Yuan, Li Qiao, Qiliang Lou… in Cell Death Discovery (2024)

Article

Systematic Mendelian Randomization Exploring Druggable Genes for Hemorrhagic Strokes

Patients with hemorrhagic stroke have high rates of morbidity and mortality, and drugs for prevention are very limited. Mendelian randomization (MR) analysis can increase the success rate of drug development b...

Lun-Zhe Yang, Yong Yang, Chuan Hong, Qi-Zhe Wu, **ong-Jie Shi… in Molecular Neurobiology (2024)

Article

IL-27 disturbs lipid metabolism and restrains mitochondrial activity to inhibit γδ T17 cell-mediated skin inflammation

IL-17+ γδ T cells (γδ T17) are kick-starters of inflammation due to their strict immunosurveillance of xenobiotics or cellular damages and rapid response to pro-inflammatory stimulators. IL-27 is a well-recogn...

Mingyue Zhang, Dehai Li, **g Zhu, Xue **a, Hua Zhang, Jie Wu… in Cell Death & Disease (2024)

Article

The Toxoplasma secreted effector TgWIP modulates dendritic cell motility by activating host tyrosine phosphatases Shp1 and Shp2

The obligate intracellular parasite Toxoplasma gondii causes life-threatening toxoplasmosis to immunocompromised individuals. The pathogenesis of Toxoplasma relies on its swift dissemination to the central nervou...

Pavel Morales, Abbigale J. Brown… in Cellular and Molecular Life Sciences (2024)

Article

Ningetinib, a novel FLT3 inhibitor, overcomes secondary drug resistance in acute myeloid leukemia

FMS-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) is a common mutation type in acute myeloid leukemia (AML) and is usually associated with poor patient prognosis. With advancements in molecular...

Chuhong Hu, Yvyin Zhang, Jie Yang, Yanli Xu… in Cell Communication and Signaling (2024)