897 Result(s)

Article

Synergistic induction of mitotic pyroptosis and tumor remission by inhibiting proteasome and WEE family kinases

Mitotic catastrophe (MC), which occurs under dysregulated mitosis, represents a fascinating tactic to specifically eradicate tumor cells. Whether pyroptosis can be a death form of MC remains unknown. Proteasom...

Zhan-Li Chen, Chen **e, Wei Zeng, Rui-Qi Huang… in Signal Transduction and Targeted Therapy (2024)

Article

Cancer stem cells: advances in knowledge and implications for cancer therapy

Cancer stem cells (CSCs), a small subset of cells in tumors that are characterized by self-renewal and continuous proliferation, lead to tumorigenesis, metastasis, and maintain tumor heterogeneity. Cancer cont...

**an**g Chu, Wentao Tian, Jiaoyang Ning… in Signal Transduction and Targeted Therapy (2024)

Article

Semaphorin 3C (Sema3C) reshapes stromal microenvironment to promote hepatocellular carcinoma progression

More than 90% of hepatocellular carcinoma (HCC) cases develop in the presence of fibrosis or cirrhosis, making the tumor microenvironment (TME) of HCC distinctive due to the intricate interplay between cancer-...

Hao Peng, Meng Yang, Kun Feng, Qingpeng Lv… in Signal Transduction and Targeted Therapy (2024)

Article

Targeting a disintegrin and metalloprotease (ADAM) 17-CD122 axis enhances CD8⁺ T cell effector differentiation and anti-tumor immunity

CD8⁺ T cell immune responses are regulated by multi-layer networks, while the post-translational regulation remains largely unknown. Transmembrane ectodomain shedding is an important post-translational process or...

Lina Sun, Anjun Jiao, Haiyan Liu, Renyi Ding… in Signal Transduction and Targeted Therapy (2024)

Article

USP21-mediated G3BP1 stabilization accelerates proliferation and metastasis of esophageal squamous cell carcinoma via activating Wnt/β-Catenin signaling

Lacking effective therapeutic targets heavily restricts the improvement of clinical prognosis for patients diagnosed with esophageal squamous cell carcinoma (ESCC). Ubiquitin Specific Peptidase 21 (USP21) is d...

Jiazhong Guo, Yunpeng Zhao, Huacong Sui, Lei Liu, Fanrong Liu, Lingxiao Yang… in Oncogenesis (2024)

Article

Optimized RNA interference therapeutics combined with interleukin-2 mRNA for treating hepatitis B virus infection

This study aimed to develop a pan-genotypic and multifunctional small interfering RNA (siRNA) against hepatitis B virus (HBV) with an efficient delivery system for treating chronic hepatitis B (CHB), and explo...

Wen**g Zai, Min Yang, Kuan Jiang, Juan Guan… in Signal Transduction and Targeted Therapy (2024)

Article

Neoadjuvant camrelizumab (an anti-PD-1 antibody) plus chemotherapy or apatinib (a VEGFR-2 inhibitor) for initially unresectable stage II–III non-small-cell lung cancer: a multicentre, two-arm, phase 2 exploratory study

This multicentre, two-arm, phase 2 study aimed to explore the efficacy and safety of neoadjuvant camrelizumab plus chemotherapy or apatinib in patients with initially unresectable stage II–III non-small-cell l...

Haoran **a, Han Zhang, Zheng Ruan… in Signal Transduction and Targeted Therapy (2024)

Article

Genetically programmable cell membrane-camouflaged nanoparticles for targeted combination therapy of colorectal cancer

Cell membrane-camouflaged nanoparticles possess inherent advantages derived from their membrane structure and surface antigens, including prolonged circulation in the bloodstream, specific cell recognition and...

Yun Yang, Qingya Liu, Meng Wang, Lang Li… in Signal Transduction and Targeted Therapy (2024)

Article

Nonconserved epitopes dominate reverse preexisting T cell immunity in COVID-19 convalescents

The herd immunity against SARS-CoV-2 is continuously consolidated across the world during the ongoing pandemic. However, the potential function of the nonconserved epitopes in the reverse preexisting cross-rea...

**n Wang, Jie Zhang, Maoshun Liu, Yuanyuan Guo… in Signal Transduction and Targeted Therapy (2024)

Article

Farnesyltransferase inhibitor lonafarnib suppresses respiratory syncytial virus infection by blocking conformational change of fusion glycoprotein

Respiratory syncytial virus (RSV) is the major cause of bronchiolitis and pneumonia in young children and the elderly. There are currently no approved RSV-specific therapeutic small molecules available. Using ...

Qi Yang, Bao Xue, Fengjiang Liu, Yongzhi Lu… in Signal Transduction and Targeted Therapy (2024)

Article

First-line penpulimab (an anti-PD1 antibody) and anlotinib (an angiogenesis inhibitor) with nab-paclitaxel/gemcitabine (PAAG) in metastatic pancreatic cancer: a prospective, multicentre, biomolecular exploratory, phase II trial

Metastatic pancreatic cancer (mPC) has a dismal prognosis. Herein, we conducted a prospective, multicentre, single-arm, phase II trial evaluating the efficacy and safety of penpulimab and anlotinib in combinat...

Huizi Sha, Fan Tong, Jiayao Ni, Yi Sun… in Signal Transduction and Targeted Therapy (2024)

Article

Real-world effectiveness of early insulin therapy on the incidence of cardiovascular events in newly diagnosed type 2 diabetes

Early insulin therapy is capable to achieve glycemic control and restore β-cell function in newly diagnosed type 2 diabetes (T2D), but its effect on cardiovascular outcomes in these patients remains unclear. I...

Sihui Luo, Xueying Zheng, Wei Bao, Sheng Nie… in Signal Transduction and Targeted Therapy (2024)

Article

Correction: Combined inhibition of JAK2-STAT3 and SMO-GLI1/tGLI1 pathways suppresses breast cancer stem cells, tumor growth, and metastasis

Daniel Doheny, Sherona Sirkisoon, Richard L. Carpenter, Noah Reeve Aguayo… in Oncogene (2024)

Article

Correction: Inhibition of the transcriptional kinase CDK7 overcomes therapeutic resistance in HER2-positive breast cancers

Bowen Sun, Seth Mason, Robert C. Wilson, Starr E. Hazard, Yubao Wang, Rong Fang… in Oncogene (2024)

Article

Correction: Targeting STAT3 by a small molecule suppresses pancreatic cancer progression

Huang Chen, Aiwu Bian, Lian-fang Yang, Xuan Yin, Jie Wang, Chaowen Ti… in Oncogene (2024)

Article

The DNA damage-independent ATM signalling maintains CBP/DOT1L axis in MLL rearranged acute myeloid leukaemia

The long-term maintenance of leukaemia stem cells (LSCs) is responsible for the high degree of malignancy in MLL (mixed-lineage leukaemia) rearranged acute myeloid leukaemia (AML). The DNA damage response (DDR) a...

Guangming Wang, Wenjun Zhang, Jie Ren, Yu Zeng, **uyong Dang, … in Oncogene (2024)

Article

Macrophages in cardiovascular diseases: molecular mechanisms and therapeutic targets

The immune response holds a pivotal role in cardiovascular disease development. As multifunctional cells of the innate immune system, macrophages play an essential role in initial inflammatory response that oc...

Runkai Chen, Hongrui Zhang, Botao Tang… in Signal Transduction and Targeted Therapy (2024)

Article

Natural evidence of coronaviral 2′-O-methyltransferase activity affecting viral pathogenesis via improved substrate RNA binding

Previous studies through targeted mutagenesis of K-D-K-E motif have demonstrated that 2′-O-MTase activity is essential for efficient viral replication and immune evasion. However, the K-D-K-E catalytic motif o...

Jikai Deng, Shimin Yang, Yingjian Li, Xue Tan… in Signal Transduction and Targeted Therapy (2024)

Article

Targeting BCL9/BCL9L enhances antigen presentation by promoting conventional type 1 dendritic cell (cDC1) activation and tumor infiltration

Conventional type 1 dendritic cells (cDC1) are the essential antigen-presenting DC subset in antitumor immunity. Suppressing B-cell lymphoma 9 and B-cell lymphoma 9-like (BCL9/BCL9L) inhibits tumor growth and ...

Fenglian He, Zhongen Wu, Chenglong Liu… in Signal Transduction and Targeted Therapy (2024)

Article

Initial COVID-19 severity influenced by SARS-CoV-2-specific T cells imprints T-cell memory and inversely affects reinfection

The immunoprotective components control COVID-19 disease severity, as well as long-term adaptive immunity maintenance and subsequent reinfection risk discrepancies across initial COVID-19 severity, remain uncl...

Gang Yang, **peng Cao, Jian Qin, **nyue Mei… in Signal Transduction and Targeted Therapy (2024)