42 Result(s)

Article

Correction: Correlations of FCGR2A 131R/H and FCGR3A 158V/F Polymorphisms with the Susceptibility of Peri-implantitis in Chinese Han Population

Peng Li, Bingzhuo Chen, Liang Zhao, Feng Yang, Zhu Zhang… in Molecular Biotechnology (2024)

Article

De novo design of buttressed loops for sculpting protein functions

In natural proteins, structured loops have central roles in molecular recognition, signal transduction and enzyme catalysis. However, because of the intrinsic flexibility and irregularity of loop regions, orga...

Hanlun Jiang, Kevin M. Jude, Kejia Wu, Jorge Fallas, George Ueda… in Nature Chemical Biology (2024)

Article

Structural basis of a small monomeric Clivia fluorogenic RNA with a large Stokes shift

RNA-based fluorogenic modules have revolutionized the spatiotemporal localization of RNA molecules. Recently, a fluorophore named 5-((Z)-4-((2-hydroxyethyl)(methyl)amino)benzylidene)-3-methyl-2-((E)-styryl)-3,5-d...

Kaiyi Huang, Qianqian Song, Mengyue Fang, Deqiang Yao, **n Shen… in Nature Chemical Biology (2024)

Article

Tumor-repopulating cells evade ferroptosis via PCK2-dependent phospholipid remodeling

Whether stem-cell-like cancer cells avert ferroptosis to mediate therapy resistance remains unclear. In this study, using a soft fibrin gel culture system, we found that tumor-repopulating cells (TRCs) with st...

Zhe Li, Zhi-min Xu, Wei-peng Chen, **ao-**g Du, Chun-xian Ou… in Nature Chemical Biology (2024)

Article

Author Correction: Engineering a precise adenine base editor with minimal bystander editing

Liang Chen, Shun Zhang, Niannian Xue, Mengjia Hong… in Nature Chemical Biology (2024)

Article

Author Correction: Fructose-1,6-bisphosphatase 1 dephosphorylates and inhibits TERT for tumor suppression

Min Li, Zheng Wang, **g**g Tao, Hongfei Jiang, Huang Yang… in Nature Chemical Biology (2024)

Article

Author Correction: Phage-assisted evolution of compact Cas9 variants targeting a simple NNG PAM

Tao Qi, Yao Wang, Yuan Yang, Siqi Gao, **gtong Liu, Qiang Huang… in Nature Chemical Biology (2024)

Article

The Role of microRNA-23a-3p in the Progression of Human Aging Process by Targeting FOXO3a

Aging results in deterioration of body functions and, ultimately, death. miRNAs contribute to the regulation of aging. The aim of this study was to explore the contribution of miRNAs to aging and senescence-re...

Shan Wang, Ying Sun, Lan Yao, Yunli **ng, Huayu Yang, Qing Ma in Molecular Biotechnology (2024)

Article

Author Correction: An engineered hypercompact CRISPR-Cas12f system with boosted gene-editing activity

Tong Wu, Chang Liu, Siyuan Zou, Ruitu Lyu, Bowei Yang, Hao Yan… in Nature Chemical Biology (2024)

Article

Identification of the Shared Gene Signatures of HCK, NOG, RNF125 and Biological Mechanism in Pediatric Acute Lymphoblastic Leukaemia and Pediatric Sepsis

The shared mechanisms between pediatric acute lymphoblastic leukaemia (ALL) and pediatric sepsis are currently unclear. This study was aimed to explore the shared key genes of pediatric ALL and pediatric sepsi...

Ying-** **ao, Yu-Cai Cheng, Chun Chen, Hong-Man Xue, Mo Yang… in Molecular Biotechnology (2023)

Article

SIRT1 Inhibition-Induced Mitochondrial Damage Promotes GSDME-Dependent Pyroptosis in Hepatocellular Carcinoma Cells

Hepatocellular carcinoma (HCC) is a malignant tumor that affects the liver and poses a significant threat to human health. Further investigation is necessary to fully understand the role of SIRT1, a protein li...

Di Liu, Junhao Liu, Kejun Liu, Yanchao Hu, **ming Feng, Yang Bu… in Molecular Biotechnology (2023)

Article

LncRNA MIR17HG Suppresses Breast Cancer Proliferation and Migration as ceRNA to Target FAM135A by Sponging miR-454-3p

Breast cancer is one of the most common malignant tumors in women, and causes a large number of cancer-related deaths. The main cause of death of breast cancer patients is tumor recurrence and metastasis. Rece...

**g**g Xu, Meishun Hu, Yang Gao, Yishu Wang, **aoning Yuan… in Molecular Biotechnology (2023)

Article

FGF2 Functions in H₂S’s Attenuating Effect on Brain Injury Induced by Deep Hypothermic Circulatory Arrest in Rats

Deep hypothermic circulatory arrest (DHCA) can protect the brain during cardiac and aortic surgery by cooling the body, but meanwhile, temporary or permanent brain injury may arise. H₂S protects neurons and the c...

Yu-**ang Zhu, Qin Yang, You-Peng Zhang, Zhi-Gang Liu in Molecular Biotechnology (2023)

Article

Anticancer and Biological Effects of Some Natural Compounds and Theoretical Investigation of them Against RdRP of SARS-COV-2: In Silico and In Vitro Studies

In this study, Skullcapflavone I and Skullcapflavone II molecules showed good inhibitory activities against α-glucosidase and sorbitol dehydrogenase enzymes with IC50 values of 102.66 ± 8.43 and 95.04 ± 11.52 ...

**g Zhang, **gyu Feng, Yang Li, Jiguo Wang, Panyan Mo… in Molecular Biotechnology (2023)

Article

Metastasis-Related Signature for Clinically Predicting Prognosis and Tumor Immune Microenvironment of Osteosarcoma Patients

Osteosarcoma is the most prevalent clinical malignant bone tumor in adolescents. The prognosis of metastatic osteosarcoma is still very poor. The aim of our study was to investigate the clinical diagnosis and ...

Qing Zhang, Zhi** Deng, Yongkun Yang in Molecular Biotechnology (2023)

Article

miR-26b Targets CEP135 Gene to Regulate Nasopharyngeal Carcinoma Proliferation and Migration by NF-κB Pathway

To screen microRNAs (miRNAs) and analyze their role in the nasopharyngeal carcinoma (NPC) development through differential analysis and cytological validation of the nasopharyngeal carcinoma dataset. The Gene ...

Guangrun Yang, Jiafu Zhou, Zhong Guo, Lixia Fan, Bowen Chen… in Molecular Biotechnology (2023)

Article

Author Correction: NADP modulates RNA m⁶A methylation and adipogenesis via enhancing FTO activity

Lina Wang, Chengli Song, Na Wang, Songyu Li, Qiaoling Liu… in Nature Chemical Biology (2023)

Article

LINC00460 Promotes Cutaneous Squamous Cell Carcinoma Progression Through Stabilizing ELAVL1 Protein

Long intergenic noncoding ribonucleic acid (lncRNA) 460 is reportedly associated with carcinogenesis and progression in various types of cancer. However, the mechanisms underlying its action in cutaneous squam...

Chunli Xue, Zuxian Yang, Ben Yang, Hailin **ong, Wei Ye in Molecular Biotechnology (2023)

Article

Knockdown of SDC-1 Gene Alleviates the Metabolic Pathway for the Development of MODS

This study aims to reveal the metabolic differences between SDC-1 knockout mice and wild-type mice and the metabolic differences caused by shock in SDC-1 knockout mice by integrating transcriptomics and metabo...

Jiangang **e, Yuexiang Ma, Yang Huang, Qianmei Wang, Yunyun Xu… in Molecular Biotechnology (2023)

Article

Publisher Correction: Small molecule agonist of mitochondrial fusion repairs mitochondrial dysfunction

Yingjie Guo, Huan Zhang, Chen Yan, Birong Shen, Yue Zhang… in Nature Chemical Biology (2023)