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Article
Open AccessFirst-line high-dose therapy and autologous blood stem cell transplantation in patients with primary central nervous system non-Hodgkin lymphomas—a single-centre experience in 61 patients
Primary central nervous system non-Hodgkin lymphomas (PCNS-NHLs) are extranodal B-cell lymphomas with poor prognosis. The role of high-dose therapy (HDT) followed by autologous blood stem cell transplantation ...
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Article
Open AccessMulticenter validation of cancer gene panel-based next-generation sequencing for translational research and molecular diagnostics
The simultaneous detection of multiple somatic mutations in the context of molecular diagnostics of cancer is frequently performed by means of amplicon-based targeted next-generation sequencing (NGS). However,...
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Article
Open AccessEphrinB2 repression through ZEB2 mediates tumour invasion and anti-angiogenic resistance
Diffuse invasion of the surrounding brain parenchyma is a major obstacle in the treatment of gliomas with various therapeutics, including anti-angiogenic agents. Here we identify the epi-/genetic and microenvi...
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Article
Chronophin is a glial tumor modifier involved in the regulation of glioblastoma growth and invasiveness
Glioblastoma is the most aggressive primary brain tumor in adults. Although the rapid recurrence of glioblastomas after treatment is a major clinical challenge, the relationships between tumor growth and intra...
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Article
Klassifikation von Gliomen
Die diagnostische Einteilung von Gliomen erfolgt traditionell histologisch auf Basis der Klassifikation der Weltgesundheitsorganisation (WHO) für Tumoren des zentralen Nervensystems. In den letzten Jahren wurd...
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Article
miRNA-145 is downregulated in atypical and anaplastic meningiomas and negatively regulates motility and proliferation of meningioma cells
Meningiomas are frequent, mostly benign intracranial or spinal tumors. A small subset of meningiomas is characterized by histological features of atypia or anaplasia that are associated with more aggressive bi...
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Article
Toxicity and survival in primary glioblastoma patients treated with concomitant plus adjuvant temozolomide versus adjuvant temozolomide: results of a single-institution, retrospective, matched-pair analysis
To compare survival and hematological toxicity rates between two postoperative therapy regimens in patients with primary glioblastoma (GBM), namely temozolomide (TMZ) concomitant to radiation, followed by adju...
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Article
Downregulation of PRDX1 by promoter hypermethylation is frequent in 1p/19q-deleted oligodendroglial tumours and increases radio- and chemosensitivity of Hs683 glioma cells in vitro
Deletions of chromosomal arms 1p and 19q are frequent in oligodendroglial tumours and linked to radio- and chemotherapy response as well as longer survival. The molecular mechanisms underlying this clinically ...
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Article
RNAi screening in glioma stem-like cells identifies PFKFB4 as a key molecule important for cancer cell survival
The concept of cancer stem-like cells (CSCs) has gained considerable attention in various solid tumors including glioblastoma, the most common primary brain tumor. This sub-population of tumor cells has been i...
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Article
De-repression of CTGF via the miR-17-92 cluster upon differentiation of human glioblastoma spheroid cultures
All-trans retinoic acid is a potent promoter of cellular differentiation processes, which is used in cancer therapy. Glioblastoma spheroid cultures are enriched in tumor-initiating cells, and provide a model to t...
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Article
Hirnmetastasen
Die Resektion ist heute eine wichtige Säule in der Therapie von Hirnmetastasen. Die Operation selbst hat durch neue Technologien und bildgebende Verfahren ein hohes Maß an Sicherheit gewonnen. Durch prospektiv...
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Article
Gene expression profiling suggests primary central nervous system lymphomas to be derived from a late germinal center B cell
To characterize the molecular origin of primary lymphomas of the central nervous system (PCNSL), 21 PCNSLs of immunocompetent patients were investigated by microarray-based gene expression profiling. Compariso...
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Article
Hypermethylation and transcriptional downregulation of the CITED4 gene at 1p34.2 in oligodendroglial tumours with allelic losses on 1p and 19q
Deletions of chromosomal arms 1p and 19q are frequent in oligodendroglial tumours and have been associated with sensitivity to radio- and chemotherapy as well as favourable prognosis. By using microarray-based...
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Article
Frequent loss of chromosome 9, homozygous CDKN2A/p14ARF/CDKN2B deletion and low TSC1 mRNA expression in pleomorphic xanthoastrocytomas
The molecular pathogenesis of pleomorphic xanthoastrocytoma (PXA), a rare astrocytic brain tumor with a relatively favorable prognosis, is still poorly understood. We characterized 50 PXAs by comparative genom...
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Article
Niedriggradige Gliome
Die Gruppe der niedriggradigen Gliome umfasst zahlreiche, neuropathologisch differenzierbare Tumorentitäten, deren klinischer Verlauf weit weniger aggressiv als der von höhergradigen anaplastischen Gliomen und...
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Article
Supratentorial meningeal melanocytoma mimicking a convexity meningioma
Objective and importance. Meningeal melanocytomas are rare benign neuro-ectodermal tumors arising from melanocytic cells in the leptomeninges. These leptomeningeal melanocytes are found at highest density underne...
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Article
Evaluation of new 18F-labeled amino acids for brain PET
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Article
Expression of the CD34 antigen in pleomorphic xanthoastrocytomas
Pleomorphic xanthoastrocytoma (PXA) is a rare, superficially located astrocytic glioma of children and young adults, which is associated with a relatively favorable prognosis. Here we report on the expression ...
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Article
Multimodal target point assessment for stereotactic biopsy in children with diffuse bithalamic astrocytomas
Introduction.Diffuse glial tumors with bithalamic involvement are rare in children. Diagnostic assessment can be difficult as the radiological findings can be unspecific.
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Article
Die neue WHO-Klassifikation der Tumoren des Nervensystems 2000
Neue Erkenntnisse auf dem Gebiet der Neuroonkologie haben die Weltgesundheitsorganisation (WHO) veranlasst, im Jahr 2000 eine überarbeitete Klassifikation der Tumoren des Nervensystems herauszugeben. Dabei wur...