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  1. Article

    Open Access

    Pharmacodynamic change in plasma angiogenic proteins: a dose-escalation phase 1 study of the multi-kinase inhibitor lenvatinib

    Lenvatinib (E7080), an oral multi-kinase inhibitor, has inhibitory action on tumor cell proliferation and tumor angiogenesis in preclinical models. We evaluated correlations between pharmacodynamic (PD) biomar...

    Noriyuki Koyama, Kenichi Saito, Yuki Nishioka, Wataru Yusa, Noboru Yamamoto… in BMC Cancer (2014)

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  2. Article

    Open Access

    A novel flow cytometry-based cell capture platform for the detection, capture and molecular characterization of rare tumor cells in blood

    Personalized cancer treatment relies on the accurate detection of actionable genomic aberrations in tumor cells. Circulating tumor cells (CTCs) could provide an alternative genetic resource for diagnosis; howe...

    Masaru Watanabe, Masakuni Serizawa, Takeshi Sawada… in Journal of Translational Medicine (2014)

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  3. Article

    Open Access

    Circulating endothelial cells and other angiogenesis factors in pancreatic carcinoma patients receiving gemcitabine chemotherapy

    Pancreatic carcinoma is a significant cause of cancer-related death in developed countries. As the level of circulating endothelial cells (CECs) is known to increase in response to various cancers, we investig...

    Shunsuke Kondo, Hideki Ueno, Jun Hashimoto, Chigusa Morizane, Fumiaki Koizumi… in BMC Cancer (2012)

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