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  1. Article

    Open Access

    Isocitrate dehydrogenase 1 mutation drives leukemogenesis by PDGFRA activation due to insulator disruption in acute myeloid leukemia (AML)

    Acute myeloid leukemia (AML) is characterized by complex molecular alterations and driver mutations. Elderly patients show increased frequencies of IDH mutations with high chemoresistance and relapse rates despit...

    Sophie Steinhäuser, Patricia Silva, Lennart Lenk, Thomas Beder, Alina Hartmann… in Leukemia (2023)

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  2. Article

    Open Access

    Malignant transformation in a defined genetic background: proteome changes displayed by 2D-PAGE

    Cancer arises from normal cells through the stepwise accumulation of genetic alterations. Cancer development can be studied by direct genetic manipulation within experimental models of tumorigenesis. Thereby, ...

    Stephanie M Pütz, Fotini Vogiatzi, Thorsten Stiewe, Albert Sickmann in Molecular Cancer (2010)

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