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  1. No Access

    Article

    Genetic enhancement of inflammatory pain by forebrain NR2B overexpression

    N-methyl-D-aspartate (NMDA) receptors contribute to many brain functions. We studied the effect of forebrain-targeted overexpression of the NMDA receptor subunit NR2B on the response of mice to tissue injury and ...

    Feng Wei, Guo-Du Wang, Geoffrey A. Kerchner, Susan J. Kim in Nature Neuroscience (2001)

  2. No Access

    Article

    GDNF acutely modulates excitability and A-type K+ channels in midbrain dopaminergic neurons

    Glial cell line-derived neurotrophic factor (GDNF) prevents lesion-induced death of midbrain dopaminergic neurons, but its function in normal brain remains uncertain. Here we show that GDNF acutely and reversi...

    Feng Yang, Linyin Feng, Fang Zheng, Steven W. Johnson, **g Du in Nature Neuroscience (2001)

  3. No Access

    Article

    Protective effects of calcitonin gene-related peptide-mediated evodiamine on guinea-pig cardiac anaphylaxis

    Previous investigations have indicated that the pharmacological effects of evodiamine, a major alkaloidal component of the dried, unripe fruit of Evodia rutaecarpa Bentham (Rutaceae), are associated with stimulat...

    Wei-Qing Rang, Yan-Hua Du, Chang-** Hu in Naunyn-Schmiedeberg's Archives of Pharmaco… (2003)

  4. No Access

    Article

    Proteomic profiling of proteins dysregulted in Chinese esophageal squamous cell carcinoma

    Esophageal squamous cell carcinoma (ESCC) is one of the leading causes of cancer death in China. In the present study, proteins in tumors and adjacent normal esophageal tissues from 41 patients with ESCC were ...

    **ao-Li Du, Hai Hu, De-Chen Lin, Shu-Hua **a in Journal of Molecular Medicine (2007)

  5. No Access

    Article

    Interaction of MT1-MMP and laminin-5γ2 chain correlates with metastasis and invasiveness in human esophageal squamous cell carcinoma

    To gain insights into metastatic mechanisms in esophageal squamous cell carcinoma (ESCC), we established sublines (MLuB1 and MLuC1) with different capacity of spontaneous lung metastasis by subcutaneous inject...

    **ao-Ming Shen, Yu-Peng Wu, Yan-Bin Feng, Man-Li Luo in Clinical & Experimental Metastasis (2007)

  6. Article

    AICAR inhibits proliferation and induced S-phase arrest, and promotes apoptosis in CaSki cells

    The aim of the present study was to determine the effect of 5-aminoimidazole-4-carboxamide-ribonucleoside (AICAR) on proliferation, cell cycle, and apoptosis in the human epithelial cervical cancer cell line C...

    Tong-ju Guan, Feng-** Qin, Jian-hai Du, Li Geng in Acta Pharmacologica Sinica (2007)

  7. No Access

    Article

    Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21

    Xuejun Zhang and colleagues report a genome-wide association and replication studies for psoriasis, conducted in Chinese populations. They confirm previous associations in MHC and IL12B to psoriasis susceptibilit...

    Xue-Jun Zhang, Wei Huang, Sen Yang, Liang-Dan Sun, Feng-Yu Zhang in Nature Genetics (2009)

  8. No Access

    Article

    Functional roles of TRPC channels in the develo** brain

    Transient receptor potential canonical (TRPC) channels are Ca2+-permeable, nonselective cation channels formed by homomeric or heteromeric complexes of TRPC proteins that contain six transmembrane domains. These ...

    Yilin Tai, Shengjie Feng, Wanlu Du in Pflügers Archiv - European Journal of Phys… (2009)

  9. Article

    LGH00031, a novel ortho-quinonoid inhibitor of cell division cycle 25B, inhibits human cancer cells via ROS generation

    To discover novel cell division cycle 25 (CDC25) B inhibitors and elucidate the mechanisms of inhibition in cancer cells.

    Yu-bo Zhou, Xu Feng, Li-na Wang, Jun-qing Du, Yue-yang Zhou in Acta Pharmacologica Sinica (2009)

  10. No Access

    Article

    Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus

    Xuejun Zhang and colleagues report results of a genome-wide association study of systemic lupus erythematosus (SLE) in a Chinese Han population. Their work identifies nine new SLE susceptibility loci and revea...

    Jian-Wen Han, Hou-Feng Zheng, Yong Cui, Liang-Dan Sun, Dong-Qing Ye in Nature Genetics (2009)

  11. No Access

    Article

    Effects of 60-day NO2 fumigation on growth, oxidative stress and antioxidative response in Cinnamomum camphora seedlings

    To study the oxidative stress and antioxidative response of Cinnamomum camphora seedlings exposed to nitrogen dioxide (NO2) fumigation.

    Zhuo-mei Chen, Ying-xu Chen, Guo-jian Du in Journal of Zhejiang University SCIENCE B (2010)

  12. No Access

    Article

    Fluorescent Property of the Gd3+-Doped Terbium Complexes and Crystal Structure of [Tb(TPTZ)(H2O)6]Cl3·3H2O

    The complex of Tb(TPTZ)Cl3·3H2O was synthesized by adding the ethyl alcohol solution of TbCl3 (1 mmol) to the solution of 2,4,6-tris-(2-pyridyl)-s-triazine(TPTZ,1 mmol) with constant stirring. The solution which ...

    Yan-Fang Zhao, Yong-Liang Zhao, Feng Bai, **ao-yan Wei in Journal of Fluorescence (2010)

  13. No Access

    Article

    Association analyses identify six new psoriasis susceptibility loci in the Chinese population

    Xue-Jun Zhang and colleagues report genome-wide association analyses identifying six new susceptibility loci in the Chinese population.

    Liang-Dan Sun, Hui Cheng, Zai-**ng Wang, An-** Zhang, Pei-Guang Wang in Nature Genetics (2010)

  14. No Access

    Article

    Association of the NFKBIA gene polymorphisms with susceptibility to autoimmune and inflammatory diseases: a meta-analysis

    To quantitatively summarize the association of NFKBIA gene polymorphisms with autoimmune and inflammatory diseases.

    Guo-Long Zhang, Yan-Feng Zou, **ao-Liang Feng, He-Jian Shi in Inflammation Research (2011)

  15. Article

    Apoptosis induced by genipin in human leukemia K562 cells: involvement of c-Jun N-terminal kinase in G2/M arrest

    To investigate the effect of genipin on apoptosis in human leukemia K562 cells in vitro and elucidate the underlying mechanisms.

    Qian Feng, Hou-li Cao, Wei Xu, **ao-rong Li, Yan-qin Ren in Acta Pharmacologica Sinica (2011)

  16. Article

    Open Access

    Involvement of Leptin Receptor Long Isoform (LepRb)-STAT3 Signaling Pathway in Brain Fat Mass- and Obesity-Associated (FTO) Downregulation during Energy Restriction

    Obesity is an important risk factor for cardiovascular disease, diabetes and certain cancers. The fat mass- and obesity-associated (FTO) gene is tightly associated with the pathophysiology of obesity, whereas the...

    Pei Wang, Feng-Jiao Yang, Hui Du, Yun-Feng Guan, Tian-Ying Xu in Molecular Medicine (2011)

  17. No Access

    Article

    The genome of the mesopolyploid crop species Brassica rapa

    The Brassica rapa Genome Sequencing Project Consortium reports the draft genome of the B. rapa accession Chiifu-401-42, an inbred Chinese cabbage line. The B. rapa genome should provide a useful reference genome ...

    **aowu Wang, Hanzhong Wang, Jun Wang, Rifei Sun, Jian Wu, Shengyi Liu in Nature Genetics (2011)

  18. Article

    Open Access

    A new method of lower extremity immobilization in radiotherapy

    We developed a new method for immobilization of the fix lower extremities by using a thermoplastic mask, a carbon fiber base plate, a customized headrest, and an adjustable angle holder. The lower extremities ...

    Xuhai Zheng, Tangzhi Dai, **aochuan Shu, Yuanxue Pu, Gang Feng in Radiation Oncology (2012)

  19. No Access

    Article

    Quantitation of Plasma Circulating DNA Using Quantitative PCR for the Detection of Hepatocellular Carcinoma

    Circulating DNA is a potential biomarker for tumor diagnosis and prognosis. This study was aimed to quantify the circulating DNA in plasma from patients with hepatocellular carcinoma (HCC) using quantitative P...

    Zhaohui Huang, Dong Hua, Yu Hu, Zhihong Cheng, **ke Zhou in Pathology & Oncology Research (2012)

  20. No Access

    Article

    Exome sequencing identifies MVK mutations in disseminated superficial actinic porokeratosis

    Xue-Jun Zhang, Jun Wang and colleagues identify mutations in MVK in disseminated superficial actinic porokeratosis, a disorder characterized by defects in epidermal keratinization. MVK encodes mevalonate kinase, ...

    Sheng-Quan Zhang, Tao Jiang, Min Li, **n Zhang, Yun-Qing Ren in Nature Genetics (2012)

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