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Pentoxifylline in severe sepsis: a double-blind, randomized placebo-controlled study
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Endotoxin inhibits heat shock protein 70 (HSP70) expression in peripheral blood mononuclear cells of patients with severe sepsis
Objective: To investigate the ex vivo endotoxin-inducible heat shock protein 70 (HSP70) expression in the peripheral blood mononuclear cells (PBMC) of patients with severe sepsis in orde...
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Procalcitonin as a marker of severity in septic shock
Background/aims: Procalcitonin (PCT) was shown to be related to the severity of bacterial infection and is recommended as a new parameter of inflammation and infection. To evaluate the prognostic value in septic...
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Article
Vorteile der assistierten Spontanatmung
Spontaneous breathing with Biphasic Positive Airway Pressure (BIPAP) or Airway Pressure Release Ventilation (APRV) caused a reduction in intrapulmonary shunting and dead space ventilation and improvement in a...
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Sex dimorphism and sepsis: a novel approach
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Pilot Study Assessing TNF Gene Polymorphism as a Prognostic Marker for Disease Progression in Neonates with Sepsis
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The PstI polymorphism of the endotoxin-inducible heat-shock protein 70–2 gene does not affect messenger RNA level in human whole-blood cultures
Objective: To determine whether the human leukocyte antigen linked biallelic heat-shock protein 70–2 (HSP70–2) gene polymorphism is associated with variable HSP70–2 messenger RNA express...
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The common functional C(−159)T polymorphism within the promoter region of the lipopolysaccharide receptor CD14 is not associated with sepsis development or mortality
Sepsis is characterised by a systemic inflammatory response to bacterial products during infection, which interestingly both in humans and animal models is gender associated with a higher susceptibility of mal...
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Increased susceptibility to apoptosis in circulating lymphocytes of critically ill patients
Background and aims: Lymphocyte apoptosis may influence immune responsiveness in systemic inflammation. Therefore, we investigated whether early signs of apoptosis (i.e., annexin-V bindi...
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The influence of endotoxin on the expression of the ORL-1 receptor
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Somatotropic axis dysfunction in critically ill patients: altered response to growth hormone-releasing hormone
Wachstumshormon (GH) hat neben anabolen Wirkungen auch immunmodulatorische Effekte. Der Einfluss von Wachstumshormon auf das Immunsystem wird kontrovers diskutiert. In der vorliegenden Studie wird die Funktio...
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Protective functions of intracellular heat-shock protein (HSP) 70-expression in patients with severe sepsis
Intracellular expression of heat-shock-protein 70 (HSP70) arose early in evolutionary development as a tool to protect cellular homeostasis. HSP70 detects proteins that are incorrectly folded or denatured. Th...
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Postoperative Schmerztherapie in Deutschland Ergebnisse einer Umfrage
Fragestellung. In einer Umfrage sollte eine Bestandsaufnahme zur Praxis der postoperativen Schmerztherapie in Deutschland erfolgen.
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Kinetic and reversibility of mechanical ventilation-associated pulmonary and systemic inflammatory response in patients with acute lung injury
Objective. To investigate the kinetic and reversibility of mechanical ventilation-associated pulmonary and systemic inflammatory response in patients with acute lung injury (ALI).
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Postoperative Analgesie mit Tramadol und Metamizol
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Apoptose als Pathomechanismus in der Sepsis
Die Sepsis gehört nach wie vor zu den häufigsten Todesursachen bei Intensivpatienten. Der Pathogenese der Erkrankung liegt ein komplexes Immungeschehen zugrunde. Neueste Erkenntnisse zeigen, dass Zellen des Ab...
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Livide Verfärbung der Hand als unerwünschtes Ereignis bei axillärer Plexusanästhesie
Im Rahmen der Durchführung einer axillären Plexusanästhesie zur Karpaltunnelspaltung kam es zur akzidentellen Punktion der A. axillaris. Im zeitlichen Zusammenhang damit trat eine livide Verfärbung der Hand au...
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Epidemiology of severe sepsis and septic shock in Germany: results from the German 'Prevalence' study
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Carbon materials and catalytic wet air oxidation of organic pollutants in wastewater
The use of carbon materials as catalytic support or direct catalyst in catalytic wet air oxidation (WAO) of organic pollutants is reviewed. The discussion covers important engineering aspects including the cha...
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Pharmakogenetik: Bestimmt das Gen die Wirksamkeit des Analgetikums?
Neue Erkenntnisse über die Struktur des Genoms und die Entdeckung genomischer Varianten haben die genetische Diagnostik auch für komplexe und akute Erkrankungen interessant werden lassen. Fragestellungen nach ...