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    Article

    Design of fast proteolysis-based signaling and logic circuits in mammalian cells

    Cellular signal transduction is predominantly based on protein interactions and their post-translational modifications, which enable a fast response to input signals. Owing to difficulties in designing new uni...

    Tina Fink, Jan Lonzarić, Arne Praznik, Tjaša Plaper… in Nature Chemical Biology (2019)

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    Article

    A tunable orthogonal coiled-coil interaction toolbox for engineering mammalian cells

    Protein interactions guide most cellular processes. Orthogonal hetero-specific protein–protein interaction domains may facilitate better control of engineered biological systems. Here, we report a tunable de n...

    Tina Lebar, Duško Lainšček, Estera Merljak, Jana Aupič… in Nature Chemical Biology (2020)