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  1. Article

    Author Correction: Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression

    Hanane Laklai, Yekaterina A. Miroshnikova, Michael W. Pickup… in Nature Medicine (2024)

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    Article

    Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression

    Impaired TGF-β signaling due to SMAD4 mutation in PDAC tumors initiates a STAT3-dependent signaling cascade that leads to increased stromal stiffening and disease progression.

    Hanane Laklai, Yekaterina A Miroshnikova, Michael W Pickup… in Nature Medicine (2016)

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    Article

    RAS-MAPK dependence underlies a rational polytherapy strategy in EML4-ALK–positive lung cancer

    Unraveling the signaling dependencies of EMLK4-ALK fusion–driven lung cancer reveals upfront combination therapy strategies.

    Gorjan Hrustanovic, Victor Olivas, Evangelos Pazarentzos, Asmin Tulpule… in Nature Medicine (2015)

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    Article

    A colorectal cancer classification system that associates cellular phenotype and responses to therapy

    Gene-expression profiles from over 1,000 colorectal tumors define six subtypes with specific phenotypical features, responses to therapy and clinical progression.

    Anguraj Sadanandam, Costas A Lyssiotis, Krisztian Homicsko… in Nature Medicine (2013)

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    Article

    Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy

    This report describes the identification of three molecularly distinct subtypes of pancreatic ductal adenocarninoma (PDA). The classical, quasimesenchymal and exocrine subtypes can further stratify tumors with...

    Eric A Collisson, Anguraj Sadanandam, Peter Olson, William J Gibb… in Nature Medicine (2011)