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Heritability: What's the point? What is it not for? A human genetics perspective

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  1. Article

    Open Access

    Genome-wide CNV analysis replicates the association between GSTM1 deletion and bladder cancer: a support for using continuous measurement from SNP-array data

    Structural variations such as copy number variants (CNV) influence the expression of different phenotypic traits. Algorithms to identify CNVs through SNP-array platforms are available. The ability to evaluate ...

    Gaëlle Marenne, Francisco X Real, Nathaniel Rothman in BMC Genomics (2012)

  2. Article

    Open Access

    Selection of SNP subsets for association studies in candidate genes: comparison of the power of different strategies to detect single disease susceptibility locus effects

    The recent advances in genoty** and molecular techniques have greatly increased the knowledge of the human genome structure. Millions of polymorphisms are reported and freely available in public databases. A...

    Emmanuelle Cousin, Jean-Francois Deleuze, Emmanuelle Genin in BMC Genetics (2006)

  3. Article

    Open Access

    Impact of the diagnosis definition on linkage detection

    Previous genome scan linkage analyses of the disease Kofendrerd Personality Disorder (KPD) with microsatellites led to detect some regions on chromosomes 1, 3, 5, and 9 that were identical for the three popula...

    Marie-Hélène Dizier, Emmanuelle Génin, Marie Claude Babron in BMC Genetics (2005)

  4. Article

    Open Access

    On the use of haplotype phylogeny to detect disease susceptibility loci

    The cladistic approach proposed by Templeton has been presented as promising for the study of the genetic factors involved in common diseases. This approach allows the joint study of multiple markers within a ...

    Claire Bardel, Vincent Danjean, Jean-Pierre Hugot, Pierre Darlu in BMC Genetics (2005)