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Endosomal integrin signals for survival

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  1. Article

    Open Access

    Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells

    The role of glutaminolysis in providing metabolites to support tumour growth is well-established, but the involvement of glutamine metabolism in invasive processes is yet to be elucidated. Here we show that no...

    Emmanuel Dornier, Nicolas Rabas, Louise Mitchell, David Novo… in Nature Communications (2017)

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  2. Article

    Open Access

    Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion

    The Rab GTPase effector, Rab-coupling protein (RCP) is known to promote invasive behaviour in vitro by controlling integrin and receptor tyrosine kinase (RTK) trafficking, but how RCP influences metastasis in viv...

    Christine Gundry, Sergi Marco, Elena Rainero, Bryan Miller… in Nature Communications (2017)

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